Question · asked by 1 review
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome: Alpha diversity (Chao1, Observed, Shannon)
- Population
- Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples
- Intervention
- Dental caries (carious oral microbiome)
- Comparison
- Caries-free / healthy oral microbiome
- Outcome
- Alpha diversity (Chao1, Observed, Shannon)
In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples · Oral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies, Adults In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded). Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) All outcomes | In adults, there was no significant caries-vs-health difference in Chao1 or Observed diversity, whereas the Shannon index differed significantly (p < 0.001). | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes | Not specified (studies published from 2012 onward included; no explicit search date reported) | 16 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.