Question · asked by 1 review
Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P): Early childhood caries experience (mean dmft)
- Population
- Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P
- Intervention
- Cleft lip and/or palate (CL/P)
- Comparison
- No cleft lip and/or palate (non-CL/P)
- Outcome
- Early childhood caries experience (mean dmft)
In the combined primary and mixed dentition, there was no evidence of a difference in caries experience between children with and without CL/P (SMD 0.09, 95% CI -0.59-0.76; 5 studies; ungraded).
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P) Caries experience in the primary dentition (dmft/dmfs/dfs/deft/ds; pooled as standardized mean difference) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P · Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021, Primary and mixed dentition In the combined primary and mixed dentition, there was no evidence of a difference in caries experience between children with and without CL/P (SMD 0.09, 95% CI -0.59-0.76; 5 studies; ungraded). Caries in children with and without orofacial clefting: A systematic review and meta-analysis. (2022) All outcomes | SMD 0.09 [-0.59, 0.76] | 5 studies · 708 participants | GRADE not reported |
Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P) Caries experience in the primary dentition (dmft/dmfs/dfs/deft/ds; pooled as standardized mean difference) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P · Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021, Mixed dentition In the mixed dentition, caries experience was significantly higher in children with CL/P (SMD 1.74, 95% CI 0.24-3.25; 4 studies; very high heterogeneity I2=99% driven by an outlier; ungraded). Caries in children with and without orofacial clefting: A systematic review and meta-analysis. (2022) All outcomes | SMD 1.74 [0.24, 3.25] | 4 studies · 789 participants | GRADE not reported |
Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P) Caries experience in the primary dentition (dmft/dmfs/dfs/deft/ds; pooled as standardized mean difference) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P · Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021, Primary dentition In the primary dentition, caries experience was significantly higher in children with CL/P than without (SMD 0.27, 95% CI 0.06-0.49; 10 studies; ungraded). Caries in children with and without orofacial clefting: A systematic review and meta-analysis. (2022) All outcomes | SMD 0.27 [0.06, 0.49] | 10 studies · 2366 participants | GRADE not reported |
Cleft lip and/or palate (CL/P) vs No cleft lip and/or palate (non-CL/P) Caries experience in the primary dentition (dmft/dmfs/dfs/deft/ds; pooled as standardized mean difference) · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P · Children with CL/P and comparable non-CL/P children across 12 countries (India, Brazil, China, Sweden, UK, USA, Germany, Greece, Ireland, Netherlands, Jordan, Thailand); studies published 1989-2021, Overall (all dentition groups) Children with CL/P have higher primary-dentition caries experience than children without CL/P (pooled random-effects SMD 0.46, 95% CI 0.15-0.77; 16 studies, 3863 children; not GRADE-rated). Caries in children with and without orofacial clefting: A systematic review and meta-analysis. (2022) All outcomes | SMD 0.46 [0.15, 0.77] | 16 studies · 3863 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Caries in children with and without orofacial clefting: A systematic review and meta-analysis. 2022 All outcomes | November 2021 (PubMed to Nov 2021; Scopus to Nov 2021; Cochrane CENTRAL to 2021; Web of Science only to June 2017) | 32 | Not applicable |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Oral Health-Related Quality of Life and Dental Caries Status in Children With Orofacial Cleft: An Indian Outlook. · 2019 · included by 1 of these review
- Caries Experience and Periodontal Status in Children and Adolescents with Cleft Lip and Palate. · 2017 · included by 1 of these review
- Dental Caries Experience in Texan Children with Cleft Lip and Palate. · 2017 · included by 1 of these review
- Caries prevalence and enamel defects in 5- and 10-year-old children with cleft lip and/or palate: A case-control study · 2015 · included by 1 of these review
- Dental Caries in the Primary Dentition of German Children with Cleft Lip, Alveolus, and Palate · 2014 · included by 1 of these review
- Oral health in 4-6 years children with cleft lip/palate: a case control study. · 2014 · included by 1 of these review
- Caries Experience of Chinese Children with Cleft Lip and Palate · 2013 · included by 1 of these review
- Caries experience in individuals with cleft lip and palate. · 2012 · included by 1 of these review
- Caries Experience in Individuals with Cleft Lip and/or Palate in China · 2010 · included by 1 of these review
- Oral health status and behaviour of Greek patients with cleft lip and palate · 2009 · included by 1 of these review
- Incidence of Dental Caries in the Primary Dentition in Children with a Cleft Lip and/or Palate · 2009 · included by 1 of these review
- Factors Influencing Early Childhood Caries of Cleft Lip and/or Palate Children Aged 18 to 36 Months in Southern Thailand · 2008 · included by 1 of these review
- Dental Caries, Oral Hygiene, and Oral Clearance in Children with Craniofacial Disorders · 2004 · included by 1 of these review
- Dental experience of cleft affected children in the west of Ireland · 2001 · included by 1 of these review
- Dental Health Indices and Caries Associated Microflora in Children with Unilateral Cleft Lip and Palate · 2000 · included by 1 of these review
- Caries, gingivitis, and dental abnormalities in preschool children with cleft lip and/or palate. · 1989 · included by 1 of these review
- Malay 2021 · included by 1 of these review
- Rawashdeh 2011 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.