Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)
Preformed metal crowns had a low annual failure rate (2.4%) in primary molars after pulpotomy, lower than amalgam in the same trial (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).
2 findings from 1 review
Progression of non-cavitated enamel caries · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; bilayer placement and nanofilled coating were described as improving survival.
1 finding from 1 review
Annual failure rate (%) 32.4%, 13.7%, 18.7%, 13.4% by insertion/coating arm
1 study · 208 participants
GRADE not reported
Fibrinogen · People with periodontitis and metabolic syndrome (no CVD; primary prevention)
1 finding from 1 review
Dental caries (by severity) · Children or adolescents
One study reported higher median caries severity among CLWH under 12 years; no meta-analytic estimate was pooled.
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
Radiological failure (periapical radiolucency) after at least 1 year · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment showed no clear difference in radiological failure (periapical radiolucency) after at least 1 year compared with multiple-visit root canal treatment (two or more visits) (moderate certainty).
1 finding from 1 review
Restorative index (RI = f/[d+f]) in the primary dentition · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P
The restorative index tended to be lower in children with CL/P (3 of 5 studies), indicating a lower proportion of restoratively managed carious teeth; not pooled (narrative; ungraded).
1 finding from 1 review
Development of endocarditis (in those with definite indication for prophylaxis) · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure
It is very uncertain whether antibiotic prophylaxis before dental procedure changes development of endocarditis (in those with definite indication for… compared with no antibiotic prophylaxis or placebo (very low certainty).
1 finding from 1 review
Dental attendance at general dentist · School children, secondary school in the UK (aged 11 to 13 years)
It is very uncertain whether criteria-based screening with specific (personalised) referral letter changes dental attendance at general dentist compared with criteria-based screening with non-specific referral letter (very low certainty).
1 finding from 1 review
Tooth loss · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive periodontitis, systemic disorders…
The review found no eligible studies for this question.
1 finding from 1 review
Pulpal disease (signs/symptoms of pulp necrosis) · Children with dentine caries in primary and permanent teeth
The reported estimate did not show a clear difference in pulpal disease after partial versus complete caries removal (ungraded).
1 finding from 1 review
RR 0.27 [0.05, 1.60]
3 studies
GRADE not reported
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Pocket closure (sites with PPD <=4 mm) · Adults with a clinical diagnosis of (chronic) periodontitis (1999 classification); studies of aggressive periodontitis, systemic disorders…
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of CDH17 (chr8q22.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of CDH17 was significantly associated with ECC in the TWAS (p = 3.32e-8); genetic association, ungraded.
1 finding from 1 review
Oral cytology (e.g. OralCDx brush biopsy, CytID) vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)
Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
The review found no eligible studies for this question.
1 finding from 1 review
Oral disease prevalence · Children with leukemia in the United Arab Emirates
Oral problems prevalence was 60%.
1 finding from 1 review
Prevalence 60
1 study
GRADE not reported
Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, conventional F-speed bitewing radiography had a summary ROC AUC of 0.72 for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
10 findings from 1 review
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