Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis: Development of endocarditis (in those with definite indication for prophylaxis)
- Population
- Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure
- Intervention
- Antibiotic prophylaxis before dental procedure
- Comparison
- placebo or no prophylaxis
- Outcome
- Development of endocarditis (in those with definite indication for prophylaxis)
It is very uncertain whether antibiotic prophylaxis before dental procedure changes development of endocarditis (in those with definite indication for… compared with no antibiotic prophylaxis or placebo (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antibiotic prophylaxis before dental procedure vs No antibiotic prophylaxis or placebo Development of endocarditis (in those with definite indication for prophylaxis) · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive… · within 180 days, Definite indication for prophylaxis It is very uncertain whether antibiotic prophylaxis before dental procedure changes development of endocarditis (in those with definite indication for… compared with no antibiotic prophylaxis or placebo (very low certainty). Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures (2022) · Cochrane All outcomes | OR 1.62 [0.57, 4.57] | 1 study · 248 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures 2022 · Cochrane All outcomes | May 2021 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.