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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Cost‐effectiveness · School children (aged 4 to 15 years), primary and secondary schools in the UK and India

The review found no eligible studies for this question.

1 finding from 1 review

Glass ionomer-based sealant vs Resin-based sealant

Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride…
    1 study · 100 participants
    Very low

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Resource implications (e.g. cost of incontinence management methods) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Pulpotomy (full or partial) vs None (single-arm pooled success proportion)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with symptomatic irreversible pulpitis due to carious pulp exposure

In symptomatic irreversible pulpitis, pooled pulpotomy success was 84% (95% CI 72-92%); not significantly different from asymptomatic (z=-1.34, p=0.18); ungraded.

1 finding from 1 review

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Clinical attachment level (CAL) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

Periodontal treatment (subgingival instrumentation, with or without… led to lower clinical attachment level (CAL) compared with no active intervention/usual care; GRADE not reported.

1 finding from 1 review

Enamel caries in primary dentition (at 5 years) vs Caries-free primary dentition

Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Enamel caries in the primary dentition is associated with about 1.6 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).

1 finding from 1 review

Referral letter based on the common-sense model (CSM) of self-regulation plus dental information guide (DIG) vs Standard referral letter

Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA

It is very uncertain whether referral letter based on the common-sense model (CSM) of… changes proportion of children with treated/untreated caries (receipt of… compared with standard referral letter (very low certainty).

1 finding from 1 review

Common genetic variants genome-wide (GWAS; ~3.9 million SNPs with MAF > 5%) vs ECC-unaffected children (per-allele case-control association)

Early childhood caries (ECC) - association at lead SNP rs74470773 (3:33958083; nearest gene(s) PDCD6IP) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

The common variant rs74470773 near PDCD6IP showed suggestive (not genome-wide significant) association with ECC (Z = -4.589, p = 4.46e-6); genetic association, ungraded.

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Caries experience · Children and adolescents (<18 years) living with HIV (CLWH)

ART was not associated with a significant difference in dental caries experience among CLWH (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in persistent parotid enlargement between ART regimens (very low certainty).

1 finding from 1 review

Sugary drinks/sweets consumption vs Children without dental caries

Dental caries (association with sugary drinks/sweets consumption) · Children (deciduous and/or permanent dentition) in low- and middle-income countries

Sugary drinks/sweets consumption was associated with about twice the odds of dental caries in LMIC children (OR 2.04, 95% CI 1.59 to 2.60; 7 studies; not GRADE-rated).

1 finding from 1 review