Healing of MRONJ (remission) · People with established (manifest) MRONJ
It is very uncertain whether teriparatide 56.5 microg weekly in addition to standard care changes healing of MRONJ (remission) compared with teriparatide 20 microg daily in addition to standard care (very low certainty).
1 finding from 1 review
Dental caries · Children (deciduous and/or permanent dentition) in low- and middle-income countries
Caregiver help with tooth brushing was associated with 65% lower odds of dental caries (OR 0.35, 95% CI 0.13 to 0.93; 3 studies; very high heterogeneity; not GRADE-rated).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Tap water irrigation (monoject syringe) led to lower presence of dry socket compared with no rinsing; GRADE not reported.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; failure rates were 3.3% and 15%.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; etch-and-rinse had a higher tabulated failure rate.
1 finding from 1 review
Color change of white spot lesion (color difference, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition
ICON resin infiltration significantly improved the color of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD 1.36, 95% CI 1.14 to 1.59; 4 studies, 458 teeth), although heterogeneity was very high (I2=98%) with a heavy outlier (Kannan); not GRADE-rated.
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between bottle-fed-only and breast-fed-only children (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Intervention not reported
Enamel acid resistance / initiation of new enamel caries lesions (in vivo, narrative)
1 finding from 1 review
Dental caries prevalence · European adolescents aged 18 years
Pooled caries prevalence was 0.74.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 15 years
Pooled caries prevalence was 0.50 (I² = 99.4%).
1 finding from 1 review
Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
Chlorhexidine gel 1% showed no clear difference in presence of dry socket compared with chlorhexidine gel 0.2%; GRADE not reported.
1 finding from 1 review
External disease-state discrimination · Oral microbiome samples from four selected case-control studies
The KEGG Orthology classifier had an approximate AUC of 0.75 in the disease-only study test set.
1 finding from 1 review
AUC 0.75
4 studies
GRADE not reported
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Retention of sealant (complete or partial retention) · Children who were regular dental attenders with caries-free first or second primary molars (public health service clinic, Brazil)
1 finding from 1 review
Effect estimate not calculable. All sealants were completely or partially retained; 40 (1 RCT). Flowable composite: 39/40 completely retained (1 partially lost) at 6 months; resin-based: 33 completely and 7 partially…
1 study · 40 participants
Low
Caries experience · European adolescents aged 18 years
Pooled caries experience was 14.98 (I² = 88.0%).
1 finding from 1 review
Number of caries in permanent teeth (DT index) · School children, primary school in Saudi Arabia
It is very uncertain whether referral to a specific dental treatment facility changes number of caries in permanent teeth (DT index) compared with generic advice letter to see a dentist (very low certainty).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Caries in upper primary incisors has the lowest tooth-specific predictive value for permanent-teeth caries (RR 1.6; single study; not GRADE-rated).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
MTA had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Diet-related noncommunicable diseases · Children and adolescents (general population, aged under 20 years)
No eligible studies were found.
1 finding from 1 review