Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

394 questions · 412 findings · 112 reviews

No studies found 51 · 12.4%GRADE not reported 41 · 10%Very low 86 · 20.9%Low 121 · 29.4%Moderate 84 · 20.4%High 29 · 7%

Intervention not reported

Adverse effects during treatment Intervention: Hyperbaric chamber/ 160 millibars versus supplementary oxygen · people suffering from high altitude illness
1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults
1 finding from 1 review

Inhaled NO vs control

Mortality before hospital discharge · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry before 3 days based on… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Intraventricular haemorrhage, Papile grade 3/4 · respiratory failure in preterm infants

Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Neurodevelopmental disability · respiratory failure in preterm infants

Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry before 3 days… compared with control (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review