Cochrane · systematic review · CD002058
Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates
Shah, SS, Ohlsson, A, Halliday, HL, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 27.3%Moderate 8 · 72.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled steroids compared with systemic corticosteroids for preventing bronchopulmonary dysplasia among all randomised infants
Population: Preterm neonates with respiratory distress
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or BPD at 36 weeks' postmenstrual age among all randomised Inhaled steroids vs systemic corticosteroids | RR 1.09 [0.88, 1.35] | 1 study · 278 participants | Moderate |
Death or BPD at 28 days Inhaled steroids vs systemic corticosteroids | RR 1.05 [0.93, 1.2] | 2 studies · 294 participants | Low |
BPD at 36 weeks' postmenstrual age Inhaled steroids vs systemic corticosteroids | RR 1.45 [0.99, 2.11] | 1 study · 278 participants | Moderate |
BPD at 28 days Inhaled steroids vs systemic corticosteroids | RR 1.21 [0.98, 1.48] | 2 studies · 294 participants | Low |
Comparison
Population: Preterm neonates with respiratory distress
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of mechanical ventilation (days) | no estimate extracted | 2 studies · 294 participants | Moderate |
Duration of supplemental oxygen (days) | no estimate extracted | 2 studies · 294 participants | Moderate |
Hyperglycaemia | RR 0.52 [0.39, 0.71] | 1 study · 278 participants | Moderate |
Patent ductus arteriosus | RR 1.64 [1.23, 2.17] | 1 study · 278 participants | Moderate |
Comparison
Population: Preterm neonates with respiratory distress
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
BPD at 36 weeks' postmenstrual age | RR 1.34 [0.94, 1.9] | 1 study · 206 participants | Moderate |
BPD at 28 days | RR 1.14 [0.96, 1.34] | 2 studies · 233 participants | Low |
Ever diagnosed as asthmatic by 7 years of age | RR 0.42 [0.19, 0.94] | 1 study · 48 participants | Moderate |