Cochrane · systematic review · CD003666
Volume‐targeted versus pressure‐limited ventilation in neonates
Klingenberg, C, Wheeler, KI, McCallion, N, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
23
current version
GRADE rated
22
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 4.3%Very low 0 · 0%Low 12 · 52.2%Moderate 10 · 43.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Volume‐targeted compared to pressure‐limited ventilation: main findings
Population: neonates up to 44 weeks' postmenstrual age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death before discharge from hospital Volume‐targeted vs pressure‐limited ventilation: main findings | RR 0.75 [0.53, 1.07] | 11 studies · 771 participants | Low |
Death or BPD (36 weeks) Volume‐targeted vs pressure‐limited ventilation: main findings | RR 0.73 [0.59, 0.89] | 8 studies · 584 participants | Moderate |
Duration of positive pressure ventilation (days) Volume‐targeted vs pressure‐limited ventilation: main findings | no estimate extracted | 12 studies · 736 participants | Moderate |
Pneumothorax Volume‐targeted vs pressure‐limited ventilation: main findings | RR 0.52 [0.31, 0.87] | 13 studies · 825 participants | Moderate |
IVH grade 3‐4 Volume‐targeted vs pressure‐limited ventilation: main findings | RR 0.53 [0.37, 0.77] | 10 studies · 712 participants | Moderate |
IVH grade 3‐4 or PVL Volume‐targeted vs pressure‐limited ventilation: main findings | RR 0.47 [0.27, 0.8] | 6 studies · 441 participants | Moderate |
BPD (supplemental oxygen at 36 weeks) Volume‐targeted vs pressure‐limited ventilation: main findings | RR 0.68 [0.53, 0.87] | 9 studies · 620 participants | Low |
Volume‐targeted compared to pressure‐limited ventilation: additional findings
Population: neonates up to 44 weeks' postmenstrual age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or BPD (28 days) Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.87 [0.64, 1.18] | 3 studies · 149 participants | Low |
Failure of mode of ventilation Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.69 [0.48, 1] | 5 studies · 445 participants | Moderate |
Addition of neuromuscular paralysis where previously not paralysed Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.32 [0.07, 1.4] | 2 studies · 75 participants | Low |
Duration of positive pressure ventilation (log data) Volume‐targeted vs pressure‐limited ventilation: additional findings | no estimate extracted | 5 studies · 381 participants | Low |
Inspired oxygen concentration % (study definition) Volume‐targeted vs pressure‐limited ventilation: additional findings | no estimate extracted | 7 studies · 324 participants | Moderate |
Any pH < 7.25 Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.8 [0.52, 1.23] | 3 studies · 98 participants | Low |
Hypocarbia pCO2 < 35 mmHg/4.7 kPa Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.49 [0.33, 0.72] | 3 studies · 98 participants | Moderate |
Respiratory acidosis pH < 7.25 and pCO2 > 60 mmHg/8 kPa Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.93 [0.51, 1.7] | 3 studies · 98 participants | Low |
Either hypocarbia or respiratory acidosis Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.68 [0.42, 1.1] | 2 studies · 37 participants | Ungraded |
Patent ductus arteriosus Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.95 [0.8, 1.12] | 10 studies · 754 participants | Low |
Air leak (any) Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.79 [0.44, 1.43] | 5 studies · 374 participants | Low |
Pulmonary interstitial emphysema Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 1.21 [0.63, 2.3] | 6 studies · 430 participants | Low |
Any IVH Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.82 [0.62, 1.08] | 5 studies · 445 participants | Low |
PVL Volume‐targeted vs pressure‐limited ventilation: additional findings | OR 0.43 [0.19, 0.98] | 7 studies · 508 participants | Moderate |
Any IVH or PVL Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.83 [0.58, 1.18] | 3 studies · 298 participants | Moderate |
BPD (supplemental oxygen at 28 days) Volume‐targeted vs pressure‐limited ventilation: additional findings | RR 0.91 [0.64, 1.3] | 4 studies · 206 participants | Low |