Findings

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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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ART/HAART duration <3 years vs ART/HAART duration >=3 years

Oral candidiasis · Children and adolescents living with HIV on ART/HAART

Oral candidiasis prevalence differed by ART duration (OR 17.93, 95% CI 3.69 to 83.12).

1 finding from 1 review

Referral letter based on the common-sense model (CSM) plus dental information guide (DIG) vs Referral letter based on the common-sense model (CSM) alone

Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA

It is very uncertain whether referral letter based on the common-sense model (CSM) plus dental… changes proportion of children with treated/untreated caries (receipt of… compared with referral letter based on the common-sense model (CSM) alone (very low certainty).

1 finding from 1 review

Fluoride-releasing resin-based sealant vs Resin-based sealant

Development of >=1 new carious lesion (caries incidence) · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    6-24 months
    N/A - insufficient quantitative information available; 69 (2 studies). Comments: Due to the different sealant materials, data reporting (split-mouth studies reported as parallel-group) and the very low number of tooth…
    2 studies · 69 participants
    Low

Multiple-surface ART restoration using high-viscosity glass ionomer vs Single-surface ART with high-viscosity GIC

Restoration survival · Children with decayed primary molar teeth

Multi-surface ART/HVGIC restorations had lower reported survival (49% at 3 years) than single-surface restorations (ungraded).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Periodontal disease prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

ART was not associated with a significant difference in periodontal disease prevalence among CLWH (very low certainty).

1 finding from 1 review

Dental caries vs Caries-free status

KEGG pathway associations · Participants in oral 16S rRNA caries microbiome studies

Phosphonate and phosphinate metabolism and glyoxylate and dicarboxylate metabolism had the lowest reported adjusted P values (0.04); no pooled effect estimate was reported.

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Kaposi's sarcoma was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).

1 finding from 1 review

Baby-led weaning (BLW) / BLISS vs Traditional complementary feeding (TCF)

Choking · Healthy children aged 6–24 months in Western industrialized countries

No statistically significant difference in choking events between BLW/BLISS and TCF was reported.

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

Healing of MRONJ · People with established (manifest) MRONJ

It is very uncertain whether hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy changes healing of MRONJ compared with conventional therapy (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in kaposi's sarcoma between ART regimens (very low certainty).

1 finding from 1 review

CBT plus hypnosis (combined package) vs usual care

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 12 years and over with painful TMD lasting 3 months or longer

CBT plus hypnosis (combined package) led to lower pain intensity compared with usual care; GRADE not reported.

1 finding from 1 review

Food and nonalcoholic beverage marketing (exposure) vs No, less, or less powerful food marketing

Food purchasing · Children and adolescents (general population, aged under 20 years)

Food marketing showed no clear association with food purchasing by or for children (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

ART was associated with lower oral candidiasis prevalence.

1 finding from 1 review