Findings

What do systematic reviews say?

666 questions · 679 findings · 337 reviews

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No studies found 349 · 51.4%GRADE not reported 63 · 9.3%Very low 75 · 11%Low 75 · 11%Moderate 87 · 12.8%High 30 · 4.4%

Massage + ultrasound and placebo ointment vs ultrasound + placebo ointment only

Quality of life—not measured · patients with extensor carpi radialis tendinitis

The review found no eligible studies for this question.

1 finding from 1 review

Deep transverse friction massage for treating lateral elbow or lateral knee tendinitis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Group C cognitive behavioural therapy: cognitive behavioural therapy + placebo vs placebo or supportive treatment

Quality of life QLS · people in the prodromal stage of psychosis

1 finding from 1 review

Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection

Quality of Life: SF‐36 (physical component) · patients with adhesive capsulitis (frozen shoulder)

1 finding from 1 review

Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Low

Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection

Quality of Life: SF‐36 (physical component) · patients with adhesive capsulitis (frozen shoulder)

1 finding from 1 review

Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Low

Summary of findings table ‐ immunostimulant vs placebo

Quality of life · adults with chronic bronchitis or chronic obstructive pulmonary disease

1 finding from 1 review

Immunostimulants versus placebo for preventing exacerbations in adults with chronic bronchitis or chronic obstructive… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 617 participants
Very low

Statins vs placebo

Quality of life · Adults with COPD

Statins led to lower quality of life compared with placebo; GRADE not reported.

1 finding from 1 review

Statins versus placebo for people with chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 3 participants
GRADE not reported

Amitriptyline vs placebo

Quality of life · adults with Major Depressive Disorder

The review found no eligible studies for this question.

1 finding from 1 review

Amitriptyline versus placebo for major depressive disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol vs placebo

Quality of life Not measured · Patients with osteoarthritis of the knee or hip

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol versus placebo for knee and hip osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
Only one study reported evidence for adjunctive aPDT in people with peri-implant disease (Al Rifaiy 2022). Data were only available for two outcomes (PPD and BOP), both reported only at three months. No studies…
Studies not reported
No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
No studies reported data for this outcome.
Studies not reported
No studies found

Flumecinol vs placebo

Quality of life · participants with cholestatic pruritus (CP)

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Manual therapy, prescribed exercises or both vs placebo

Quality of life · lateral elbow pain

The review found no eligible studies for this question.

1 finding from 1 review

Manual therapy and exercise for lateral elbow pain 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
The trials did not measure quality of life.
0 studies
No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
No studies reported data for this outcome.
Studies not reported
No studies found

Lutein with or without zeaxanthin vs placebo

Quality of life · people with AMD

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 308 participants
Moderate

Vitamin E vs placebo

Quality of life · people with AMD

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zinc vs placebo

Quality of life · people with AMD

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Quality of life · people with AMD

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 110 participants
Low

Cerebrolysin or Cerebrolysin‐like agents vs placebo

Quality of life · people with acute ischemic stroke

The review found no eligible studies for this question.

1 finding from 1 review

Cerebrolysin for acute ischaemic stroke 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Immunomodulatory interventions vs placebo

Quality of life · people with focal epilepsy

The review found no eligible studies for this question.

1 finding from 1 review

Immunomodulatory interventions for focal epilepsy 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found