Cochrane · systematic review · CD011959
Statins versus placebo for people with chronic obstructive pulmonary disease
Walsh, A, Perrem, L, Khashan, AS, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 33.3%Very low 0 · 0%Low 2 · 33.3%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Statins compared to placebo as adjunct therapy for chronic obstructive pulmonary disease (COPD)
Population: adults with chronic obstructive pulmonary disease (COPD)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of exacerbations per person‐year Statins vs placebo | no estimate extracted | 1 study · 877 participants | Moderate Downgraded: risk of bias |
Exacerbations requiring hospitalisation per person‐year Statins vs placebo | no estimate extracted | 1 study · 877 participants | Moderate Downgraded: risk of bias |
All‐cause mortality Statins vs placebo | OR 1.03 [0.61, 1.74] | 2 studies · 952 participants | Low Downgraded: risk of bias, imprecision |
COPD‐specific mortality Statins vs placebo | OR 1.25 [0.38, 4.13] | 1 study · 877 participants | Low Downgraded: risk of bias |
Quality of life Statins vs placebo | no estimate extracted | 3 studies · 3 participants | Ungraded |
Adverse events Statins vs placebo | no estimate extracted | 8 studies · 8 participants | Ungraded |