Cochrane · systematic review · CD009945
Immunomodulatory interventions for focal epilepsy
Panebianco, M, Walker, L, Marson, AG · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
3
No studies
4
Included studies
NR
No studies 4 · 57.1%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Immunomodulatory interventions compared with placebo for focal epilepsy
Population: people with focal epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Seizure freedom Immunomodulatory interventions vs placebo | no estimate extracted | NR | No studies |
50% or greater reduction in seizure frequency ‐ ITT analysis Immunomodulatory interventions vs placebo | RR 2.3 | 3 studies · 172 participants | Moderate Downgraded: imprecision |
Adverse events of glucocorticoids and immunosuppressive drugs Immunomodulatory interventions vs placebo | RR 1.16 | 1 study · 66 participants | Low Downgraded: imprecision |
Treatment withdrawal Immunomodulatory interventions vs placebo | RR 1.04 | 3 studies · 172 participants | Low Downgraded: imprecision |
Allergic reactions Immunomodulatory interventions vs placebo | no estimate extracted | NR | No studies |
Cognitive effects Immunomodulatory interventions vs placebo | no estimate extracted | NR | No studies |
Quality of life Immunomodulatory interventions vs placebo | no estimate extracted | NR | No studies |