Cochrane · systematic review · CD011275

Manual therapy and exercise for adhesive capsulitis (frozen shoulder)

Page, MJ, Green, S, Kramer, S, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library

MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
42
current version
GRADE rated
22
No studies
20
Included studies
NR
No studies 20 · 47.6%Ungraded 0 · 0%Very low 0 · 0%Low 12 · 28.6%Moderate 4 · 9.5%High 6 · 14.3%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Combination of manual therapy and exercise compared with glucocorticoid injection for adhesive capsulitis (frozen shoulder)

Population: patients with adhesive capsulitis (frozen shoulder)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported pain relief ≥ 30%
Combination of manual therapy and exercise vs glucocorticoid injection
no estimate extractedNRNo studies
Overall pain (change from baseline)
Combination of manual therapy and exercise vs glucocorticoid injection
no estimate extracted1 study · 107 participantsModerate
Downgraded: risk of bias
Function (change from baseline) Shoulder Disabilty Questionnaire 0‐100 (lower scores = better function)
Combination of manual therapy and exercise vs glucocorticoid injection
no estimate extracted1 study · 107 participantsModerate
Downgraded: risk of bias
Global assessment of treatment success Complete recovery or much improvement (self‐rated)
Combination of manual therapy and exercise vs glucocorticoid injection
RR 0.61 study · 108 participantsModerate
Downgraded: risk of bias
Active shoulder abduction
Combination of manual therapy and exercise vs glucocorticoid injection
no estimate extractedNRNo studies
Quality of life
Combination of manual therapy and exercise vs glucocorticoid injection
no estimate extractedNRNo studies
Adverse events
Combination of manual therapy and exercise vs glucocorticoid injection
RR 1.071 study · 114 participantsModerate
Downgraded: risk of bias

Combination of manual therapy, exercise, electrotherapy and placebo injection compared with glucocorticoid injection for adhesive capsulitis (frozen shoulder)

Population: patients with adhesive capsulitis (frozen shoulder)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported pain relief ≥ 30%
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extractedNRNo studies
Overall pain (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = less pain)a
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extracted2 studies · 86 participantsLow
Downgraded: risk of bias, inconsistency
Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)g
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extracted2 studies · 86 participantsLow
Downgraded: risk of bias
Global assessment of treatment success
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extractedNRNo studies
Active shoulder abduction
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extractedNRNo studies
Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life)
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extracted1 study · 49 participantsLow
Downgraded: risk of bias, inconsistency
Adverse events
Combination of manual therapy, exercise, electrotherapy and placebo injection vs glucocorticoid injection
no estimate extractedNRNo studies

Combination of manual therapy, exercise, electrotherapy and placebo injection compared with placebo injection for adhesive capsulitis (frozen shoulder)

Population: patients with adhesive capsulitis (frozen shoulder)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported pain relief ≥ 30%
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extractedNRNo studies
Overall pain (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = less pain)a
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extracted2 studies · 86 participantsLow
Downgraded: risk of bias
Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)f
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extracted2 studies · 86 participantsLow
Downgraded: risk of bias
Global assessment of treatment success
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extractedNRNo studies
Active shoulder abduction
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extractedNRNo studies
Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life)
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extracted1 study · 49 participantsLow
Downgraded: risk of bias
Adverse events
Combination of manual therapy, exercise, electrotherapy and placebo injection vs placebo injection
no estimate extractedNRNo studies

Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection compared with glucocorticoid injection for adhesive capsulitis (frozen shoulder)

Population: patients with adhesive capsulitis (frozen shoulder)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported pain relief ≥ 30%
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extractedNRNo studies
Overall pain (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = less pain)a
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extracted2 studies · 86 participantsLow
Downgraded: risk of bias
Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)f
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extracted2 studies · 86 participantsLow
Downgraded: risk of bias
Global assessment of treatment success
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extractedNRNo studies
Active shoulder abduction
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extractedNRNo studies
Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life)
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extracted1 study · 44 participantsLow
Downgraded: risk of bias
Adverse events
Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection
no estimate extractedNRNo studies

Combination of manual therapy and exercise following joint distension compared with sham ultrasound following joint distension for adhesive capsulitis (frozen shoulder)

Population: patients with adhesive capsulitis (frozen shoulder)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported pain relief ≥ 30%
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
no estimate extractedNRNo studies
Overall pain (change from baseline)
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
no estimate extracted1 study · 148 participantsHigh
Function (change from baseline) SPADI 0‐100 (lower scores = better function)
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
no estimate extracted1 study · 148 participantsHigh
Active shoulder abduction (change from baseline) Degrees
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
no estimate extracted1 study · 148 participantsHigh
Quality of life (change from baseline) SF‐36 Physical Component Score (0‐100) (lower scores = worse quality of life)
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
no estimate extracted1 study · 148 participantsHigh
Global assessment of treatment success "Success, much improved, and/or completely recovered" (self‐rated)
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
RR 1.331 study · 148 participantsHigh
Adverse events
Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension
RR 0.991 study · 149 participantsHigh

Combination of manual therapy, exercise, electrotherapy and oral NSAID compared with oral NSAID for adhesive capsulitis (frozen shoulder)

Population: patients with adhesive capsulitis (frozen shoulder)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Participant‐reported pain relief ≥ 30%
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
no estimate extractedNRNo studies
Overall pain
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
no estimate extractedNRNo studies
Function (change from baseline) Shoulder Pain and Disability Questionnaire (SPADI, 0‐100) (lower scores = better function)
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
no estimate extracted1 study · 119 participantsLow
Downgraded: risk of bias
Global assessment of treatment success "Disappearance of shoulder complaints or some pain/limitation which does not interfere with everyday life"
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
RR 1.451 study · 109 participantsLow
Downgraded: risk of bias
Active shoulder abduction
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
no estimate extractedNRNo studies
Quality of life
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
no estimate extractedNRNo studies
Adverse events Pain persisting longer than 2 hours after treatment (during the 3‐week treatment period)
Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID
RR 8.851 study · 119 participantsLow
Downgraded: risk of bias