Cochrane · systematic review · CD009138
Amitriptyline versus placebo for major depressive disorder
Leucht, C, Huhn, M, Leucht, S · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
3
No studies
2
Included studies
NR
No studies 2 · 40%Ungraded 0 · 0%Very low 1 · 20%Low 0 · 0%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Amitriptyline versus placebo for major depressive disorder
Population: adults with major depressive disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment At least 50% reduction of a depression scale (mainly Hamilton Depression Rating Scale) Amitriptyline vs placebo | OR 2.64 [2.28, 3.06] | 31 studies · 3228 participants | Moderate Downgraded: risk of bias, publication bias |
Death due to suicide Amitriptyline vs placebo | no estimate extracted | NR | No studies |
Quality of life Amitriptyline vs placebo | no estimate extracted | NR | No studies |
Acceptability of treatment Drop‐out for any reason Amitriptyline vs placebo | OR 0.71 [0.55, 0.93] | 24 studies · 2400 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Overall tolerability Drop‐out due to adverse events Amitriptyline vs placebo | OR 4.15 [2.71, 6.35] | 19 studies · 2174 participants | Moderate Downgraded: risk of bias |