What do systematic reviews say?

Antibiotics vs no treatment or placebo on top of topical antiseptics

The review found no eligible studies for this question.

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs no treatment/placebo

The review found no eligible studies for this question.

• Systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Inhaled antibiotics vs IV antibiotics

• Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

Antibiotic prophylaxis vs no treatment/placebo

The review found no eligible studies for this question.

• Interventions for the prevention of recurrent erysipelas and cellulitis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Summary of findings: Inhaled antibiotics plus IV antibiotics showed no clear difference in quality of life: number of participants achieving MCID compared with IV antibiotics only (low certainty).

• Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis 2022 · Cochrane Headline outcomes only
  RR 1.2 [0.61, 2.34]
  1 study · 16 participants
  Low

Topical quinolone vs boric acid

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical quinolone vs povidone‐iodine

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

• Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low

Antibiotic eardrops (with or without a corticosteroid) vs oral antibiotics

The review found no eligible studies for this question.

• Interventions for children with ear discharge occurring at least two weeks following grommet (ventilation tube)… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

• Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate
• Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

• Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High
• Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Topical antibiotics with steroids vs placebo/no treatment

The review found no eligible studies for this question.

• Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics at time of replacement vs no antibiotics at time of replacement

The review found no eligible studies for this question.

• Policies for replacing long‐term indwelling urinary catheters in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antibiotics vs placebo or no intervention

The review found no eligible studies for this question.

• Antibiotic prophylaxis for leptospirosis 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral antibiotics vs placebo

• Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 45 participants
  Moderate

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  1 year
  This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
  1 study · 26 participants
  Very low

Summary of findings: anti‐pseudomonal antibiotics vs placebo

• Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 245 participants
  Low

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  GRADE not reported

Single vs combination IV antibiotics

The review found no eligible studies for this question.

• Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical antibiotics with steroids vs topical steroid

• Interventions to reduce Staphylococcus aureus in the management of eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 42 participants
  Moderate