Cochrane · systematic review · CD013254
Intermittent prophylactic antibiotics for bronchiectasis
Spencer, S, Donovan, T, Chalmers, JD, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
18
No studies
3
Included studies
NR
No studies 3 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 14.3%Moderate 7 · 33.3%High 8 · 38.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
14 days on/off antibiotic regimen compared to 14 days on/off placebo regimen
Population: people with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbation frequency 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | RR 0.75 [0.61, 0.93] | NR | Moderate Downgraded: inconsistency |
Exacerbation frequency 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | no estimate extracted | NR | Moderate Downgraded: inconsistency |
Serious adverse events 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | OR 0.92 [0.63, 1.33] | NR | High |
Antibiotic resistance 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | OR 2.14 [1.36, 3.35] | NR | High |
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | no estimate extracted | NR | No studies |
Health‐related quality of life 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | no estimate extracted | NR | High |
Health‐related quality of life 14 days on/off antibiotic regimen vs 14 days on/off placebo regimen | no estimate extracted | NR | Moderate Downgraded: inconsistency |
28 days on/off antibiotic regimen compared to 28 days on/off placebo regimen
Population: people with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbation frequency 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | RR 0.92 [0.82, 1.02] | NR | High |
Exacerbation frequency 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | no estimate extracted | NR | Low Downgraded: imprecision, inconsistency |
Serious adverse events 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | OR 1 [0.68, 1.46] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Antibiotic resistance 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | OR 2.2 [1.42, 3.42] | NR | High |
Hospitalisation for pulmonary exacerbations 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | OR 0.79 [0.49, 1.29] | NR | High |
Health‐related quality of life 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | no estimate extracted | NR | Moderate Downgraded: risk of bias, imprecision |
Health‐related quality of life 28 days on/off antibiotic regimen vs 28 days on/off placebo regimen | no estimate extracted | NR | Low Downgraded: inconsistency |
14 days on/off antibiotic regimen compared to 28 days on/off antibiotic regimen
Population: people with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbation frequency 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | RR 1.02 [0.84, 1.24] | NR | Moderate Downgraded: inconsistency |
Exacerbation frequency 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | no estimate extracted | NR | No studies |
Serious adverse events 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | OR 0.83 [0.37, 1.86] | NR | Moderate Downgraded: inconsistency |
Antibiotic resistance 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | OR 1 [0.68, 1.48] | NR | Moderate Downgraded: inconsistency |
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | no estimate extracted | NR | No studies |
Health‐related quality of life 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | no estimate extracted | NR | High |
Health‐related quality of life 14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen | no estimate extracted | NR | High |