Cochrane · systematic review · CD002007
Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis
Holland, P, Jahnke, N · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
3
No studies
8
Included studies
NR
No studies 8 · 66.7%Ungraded 1 · 8.3%Very low 0 · 0%Low 2 · 16.7%Moderate 1 · 8.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: single compared with combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis ‐ short‐term effects
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in FEV1 % predicted at end of antibiotic course: absolute post‐treatment values Summary of findings: single vs combination intravenous anti‐pseudomonal antibiotic therapy | MD 5.25 | 2 studies · 93 participants | Low Downgraded: risk of bias, imprecision |
Change in sputum P aeruginosa density at end of treatment (cfu/g) Summary of findings: single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | 1 study · 76 participants | Moderate Downgraded: risk of bias, imprecision |
Additional treatment required  Summary of findings: single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Time to next course of antibiotics  Summary of findings: single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Adverse events during treatment Summary of findings: single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | 2 studies · 131 participants | Low Downgraded: risk of bias, imprecision |
Quality of life  Summary of findings: single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Summary of findings: Single compared with combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis ‐ long‐term effects
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in FEV1 (% predicted) Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Change in sputum P aeruginosa density at end of treatment (cfu/g) Â Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Additional treatment required  Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Time to next course of antibiotics  Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Adverse events during treatment Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | NR | No studies |
Quality of life Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy | no estimate extracted | 1 study · 20 participants | Ungraded |