Cochrane · systematic review · CD009730
Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis
Hurley, MN, Prayle, AP, Flume, P · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
6
No studies
5
Included studies
NR
No studies 5 · 45.5%Ungraded 0 · 0%Very low 1 · 9.1%Low 5 · 45.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Single versus combination IV antibiotics for pulmonary exacerbations in people with cystic fibrosis
Population: people with cystic fibrosis experiencing a pulmonary exacerbation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 (% predicted) absolute change Single vs combination IV antibiotics | no estimate extracted | 6 studies · 265 participants | Low Downgraded: risk of bias |
FVC (% predicted) absolute change Single vs combination IV antibiotics | no estimate extracted | 4 studies · 146 participants | Low Downgraded: risk of bias |
Time to next exacerbation (weeks) Single vs combination IV antibiotics | no estimate extracted | 1 study · 34 participants | Low Downgraded: risk of bias |
Quality of life Single vs combination IV antibiotics | no estimate extracted | NR | No studies |
Nebulised antibiotics compared to IV antibiotics for pulmonary exacerbations in people with cystic fibrosis
Population: people with cystic fibrosis experiencing a pulmonary exacerbation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FVC (% predicted) absolute change Nebulised antibiotics vs IV antibiotics | no estimate extracted | 1 study · 54 participants | Very low Downgraded: risk of bias |
Time to next exacerbation Nebulised antibiotics vs IV antibiotics | no estimate extracted | NR | No studies |
Quality of life Nebulised antibiotics vs IV antibiotics | no estimate extracted | NR | No studies |
Oral antibiotics compared to IV antibiotics for pulmonary exacerbations in people with cystic fibrosis
Population: people with cystic fibrosis experiencing a pulmonary exacerbation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 (% predicted) absolute change Oral antibiotics vs IV antibiotics | no estimate extracted | 1 study · 24 participants | Low Downgraded: risk of bias |
FVC (% predicted) absolute change Oral antibiotics vs IV antibiotics | no estimate extracted | 1 study · 24 participants | Low Downgraded: risk of bias |
Time to next exacerbation Oral antibiotics vs IV antibiotics | no estimate extracted | NR | No studies |
Quality of life Oral antibiotics vs IV antibiotics | no estimate extracted | NR | No studies |