Cochrane · systematic review · CD014959
Antibiotic prophylaxis for leptospirosis
Win, TZ, Perinpanathan, T, Mukadi, P, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
5
Included studies
NR
No studies 5 · 35.7%Ungraded 0 · 0%Very low 6 · 42.9%Low 3 · 21.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Antibiotics compared to placebo or no intervention for prophylaxis for leptospirosis
Population: farmworkers, soldiers, and people in endemic areas
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 0.15 [0.01, 2.83] | 1 study · 782 participants | Low Downgraded: risk of bias, imprecision |
Laboratory‐confirmed leptospirosis Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 0.56 [0.25, 1.26] | 5 studies · 2593 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Clinical diagnosis of infection regardless of laboratory confirmed Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 0.76 [0.53, 1.08] | 4 studies · 1653 participants | Low Downgraded: risk of bias, imprecision |
Clinical diagnosis confirmed by laboratory diagnosis Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 0.57 [0.26, 1.26] | 4 studies · 1653 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events ‐ not reported Summary of findings table ‐ Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Quality of life ‐ not reported Summary of findings table ‐ Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Non‐serious adverse events Summary of findings table ‐ Antibiotics vs placebo or no intervention | RR 10.13 [2.4, 42.71] | 3 studies · 1909 participants | Very low Downgraded: risk of bias, imprecision |
Summary of findings table ‐ Antibiotics compared to other antibiotics for prophylaxis of leptospirosis
Population: farmworkers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality ‐ not reported Summary of findings table ‐ Antibiotics vs other antibiotics | no estimate extracted | NR | No studies |
Laboratory‐confirmed leptospirosis Summary of findings table ‐ Antibiotics vs other antibiotics | RR 1.53 [0.53, 4.45] | 1 study · 137 participants | Very low Downgraded: risk of bias, imprecision |
Clinical diagnosis of leptospirosis regardless of laboratory confirmation Summary of findings table ‐ Antibiotics vs other antibiotics | RR 4.18 [0.94, 18.66] | 1 study · 137 participants | Very low Downgraded: risk of bias, imprecision |
Clinical diagnosis of leptospirosis confirmed by laboratory diagnosis Summary of findings table ‐ Antibiotics vs other antibiotics | RR 4.18 [0.94, 18.66] | 1 study · 137 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events ‐ not reported Summary of findings table ‐ Antibiotics vs other antibiotics | no estimate extracted | NR | No studies |
Quality of life ‐ not reported Summary of findings table ‐ Antibiotics vs other antibiotics | no estimate extracted | NR | No studies |
Non‐serious adverse events Summary of findings table ‐ Antibiotics vs other antibiotics | RR 1.12 [0.36, 3.48] | 1 study · 137 participants | Very low Downgraded: risk of bias, imprecision |