Cochrane · systematic review · CD013056
Antibiotics versus topical antiseptics for chronic suppurative otitis media
Head, K, Chong, L-Y, Bhutta, MF, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
10
No studies
11
Included studies
NR
No studies 11 · 52.4%Ungraded 0 · 0%Very low 7 · 33.3%Low 2 · 9.5%Moderate 1 · 4.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical antibiotics compared to acetic acid for chronic suppurative otitis media
Population: chronic suppurative otitis media
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge (1 to 2 weeks) Aminoglycosides Topical antibiotics vs acetic acid | RR 0.88 [0.72, 1.08] | 1 study · 100 participants | Very low Downgraded: risk of bias, indirectness, publication bias |
Resolution of ear discharge (after 4 weeks) ‐ not measured Topical antibiotics vs acetic acid | no estimate extracted | NR | No studies |
Quality of life ‐ not measured Topical antibiotics vs acetic acid | no estimate extracted | NR | No studies |
Ear pain, discomfort, irritation Topical antibiotics vs acetic acid | RR 0.16 [0.02, 1.34] | 2 studies · 189 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Hearing Topical antibiotics vs acetic acid | no estimate extracted | 1 study · 107 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Serious complications ‐ not measured Topical antibiotics vs acetic acid | no estimate extracted | NR | No studies |
Suspected ototoxicity Topical antibiotics vs acetic acid | no estimate extracted | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Topical antibiotics (quinolones) compared to boric acid for chronic suppurative otitis media
Population: chronic suppurative otitis media
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge (1 to 2 weeks) Quinolones Topical antibiotics (quinolones) vs boric acid | RR 1.86 [1.48, 2.35] | 1 study · 411 participants | Moderate Downgraded: publication bias |
Resolution of ear discharge (after 4 weeks) ‐ not measured Topical antibiotics (quinolones) vs boric acid | no estimate extracted | NR | No studies |
Quality of life ‐ not measured Topical antibiotics (quinolones) vs boric acid | no estimate extracted | NR | No studies |
Ear pain, discomfort, irritation Topical antibiotics (quinolones) vs boric acid | RR 0.56 [0.32, 0.98] | 2 studies · 510 participants | Low Downgraded: imprecision, publication bias |
Average change in hearing from baseline Topical antibiotics (quinolones) vs boric acid | no estimate extracted | 1 study · 390 participants | Low Downgraded: imprecision, publication bias |
Serious complications ‐ not measured Topical antibiotics (quinolones) vs boric acid | no estimate extracted | NR | No studies |
Suspected ototoxicity ‐ not measured Topical antibiotics (quinolones) vs boric acid | no estimate extracted | NR | No studies |
Topical antibiotics (quinolones) compared to povidone‐iodine for chronic suppurative otitis media
Population: chronic suppurative otitis media
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge (1 to 2 weeks) Topical antibiotics (quinolones) vs povidone‐iodine | RR 1.02 [0.82, 1.26] | 1 study · 39 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Resolution of ear discharge (after 4 weeks) ‐ not measured Topical antibiotics (quinolones) vs povidone‐iodine | no estimate extracted | NR | No studies |
Quality of life ‐ not measured Topical antibiotics (quinolones) vs povidone‐iodine | no estimate extracted | NR | No studies |
Ear pain, discomfort, irritation ‐ not measured Topical antibiotics (quinolones) vs povidone‐iodine | no estimate extracted | NR | No studies |
Hearing Topical antibiotics (quinolones) vs povidone‐iodine | no estimate extracted | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Serious complications ‐ not measured Topical antibiotics (quinolones) vs povidone‐iodine | no estimate extracted | NR | No studies |
Suspected ototoxicity Topical antibiotics (quinolones) vs povidone‐iodine | no estimate extracted | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision, publication bias |