Cochrane · systematic review · CD003871
Interventions to reduce Staphylococcus aureus in the management of eczema
George, SMC, Karanovic, S, Harrison, DA, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
20
No studies
1
Included studies
NR
No studies 1 · 4.8%Ungraded 0 · 0%Very low 9 · 42.9%Low 6 · 28.6%Moderate 5 · 23.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical steroid plus topical antibiotic compared with topical steroid for eczema
Population: children and adults with eczema
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global outcome (good or excellent improvement in symptoms or signs, or both) Topical steroid plus topical antibiotic vs topical steroid | RR 1.1 [1, 1.21] | 3 studies · 224 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change from baseline in quality of life IDQoL ranges from 0 to 30 with higher values indicating more impaired quality of life Topical steroid plus topical antibiotic vs topical steroid | no estimate extracted | 1 study · 42 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse events requiring withdrawal from treatment Topical steroid plus topical antibiotic vs topical steroid | RR 1.24 [0.21, 7.25] | 4 studies · 325 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Minor adverse events not requiring withdrawal from treatment Topical steroid plus topical antibiotic vs topical steroid | RR 0.3 [0.12, 0.78] | 2 studies · 218 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Emergence of antibiotic‐resistant micro‐organisms Topical steroid plus topical antibiotic vs topical steroid | no estimate extracted | 1 study · 65 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Global change in composite ratings scale EASI ranges from 0 to 72, objective SCORAD ranges from 0 to 83 and SCORAD ranges from 0 to 108, with higher values indicating greater severity. Topical steroid plus topical antibiotic vs topical steroid | no estimate extracted | 4 studies · 256 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
No of participants in whom S. aureus was isolated Topical steroid plus topical antibiotic vs topical steroid | RR 0.48 [0.27, 0.84] | 7 studies · 298 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Oral antibiotic compared with placebo for eczema
Population: children and adults with atopic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global outcome (good or excellent improvement in symptoms or signs, or both) Oral antibiotic vs placebo | RR 0.8 [0.18, 3.5] | 2 studies · 75 participants | Low Downgraded: risk of bias, imprecision |
Change from baseline in quality of life IDQoL ranges from 0 to 30 with higher values indicating more impaired quality of life. Oral antibiotic vs placebo | no estimate extracted | 1 study · 45 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse events requiring withdrawal from treatment Oral antibiotic vs placebo | no estimate extracted | 4 studies · 199 participants | Very low Downgraded: risk of bias, imprecision |
Minor adverse events not requiring withdrawal from treatment Oral antibiotic vs placebo | no estimate extracted | 1 study · 68 participants | Very low Downgraded: risk of bias, imprecision |
Emergence of antibiotic‐resistant micro‐organisms Oral antibiotic vs placebo | no estimate extracted | 2 studies · 98 participants | Very low Downgraded: risk of bias, imprecision |
Global change in composite ratings scale EASI ranges from 0 to 72 with higher values indicating greater severity. Oral antibiotic vs placebo | no estimate extracted | 1 study · 68 participants | Moderate Downgraded: risk of bias, imprecision |
No of participants in whom S. aureus was isolated Oral antibiotic vs placebo | RR 0.76 [0.46, 1.26] | 3 studies · 144 participants | Low Downgraded: risk of bias, imprecision |
Bleach bath compared with placebo or bath emollient for eczema
Population: children and adults with atopic dermatitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global outcome (good or excellent improvement in symptoms or signs, or both) Bleach bath vs placebo or bath emollient | RR 0.78 [0.37, 1.63] | 1 study · 36 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Change from baseline in quality of life CDLQI ranges from 0 to 30 with higher values indicating more impaired quality of life. Bleach bath vs placebo or bath emollient | no estimate extracted | 1 study · 80 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse events requiring withdrawal from treatment Bleach bath vs placebo or bath emollient | no estimate extracted | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Minor adverse events not requiring withdrawal from treatment Bleach bath vs placebo or bath emollient | RR 1 [0.35, 2.87] | 1 study · 36 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Emergence of antibiotic‐resistant micro‐organisms Bleach bath vs placebo or bath emollient | no estimate extracted | 1 study · 80 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Global change in composite ratings scale EASI ranges from 0 to 72 with higher values indicating greater severity. Bleach bath vs placebo or bath emollient | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
No of participants in whom S. aureus was isolated Bleach bath vs placebo or bath emollient | no estimate extracted | NR | No studies |