Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

111 questions · 118 findings · 48 reviews

No studies found 32 · 27.1%GRADE not reported 0 · 0%Very low 38 · 32.2%Low 36 · 30.5%Moderate 11 · 9.3%High 1 · 0.8%

Acupuncture vs sham

Multiple pregnancy rate · polycystic ovarian syndrome

True acupuncture showed no clear difference in multiple pregnancy rate compared with sham acupuncture (low certainty).

1 finding from 1 review

Long‐term GnRH agonist therapy vs no additional therapy

Multiple pregnancy rate · patients with endometriosis prior to standard IVF/ICSI

It is very uncertain whether long‐term GnRH agonist therapy changes multiple pregnancy rate compared with no additional therapy (very low certainty).

1 finding from 1 review

DHEA or testosterone vs placebo/no treatment

Multiple pregnancy · women undergoing assisted reproduction

It is very uncertain whether DHEA or testosterone changes multiple pregnancy ‐ DHEA compared with placebo/no treatment (very low certainty).

2 findings from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in multiple pregnancy per woman compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review