Cochrane · systematic review · CD000317
Intrauterine insemination versus intracervical insemination in donor sperm treatment
Kop, PAL, Mochtar, MH, O'Brien, PA, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
10
No studies
10
Included studies
NR
No studies 10 · 50%Ungraded 0 · 0%Very low 10 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intrauterine insemination versus intracervical insemination in natural cycles
Population: women starting donor sperm treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Intrauterine insemination vs intracervical insemination | OR 3.24 [0.12, 87.13] | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
Multiple pregnancy rate Intrauterine insemination vs intracervical insemination | no estimate extracted | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate Intrauterine insemination vs intracervical insemination | OR 6.18 [1.91, 20.03] | 2 studies · 76 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage rate Intrauterine insemination vs intracervical insemination | no estimate extracted | 1 study · 26 participants | Very low Downgraded: risk of bias, imprecision |
Cancellation rate ‐ natural cycles Intrauterine insemination vs intracervical insemination | no estimate extracted | NR | No studies |
Intrauterine insemination versus intracervical insemination in gonadotropin‐stimulated cycles
Population: women who are starting donor sperm treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Intrauterine insemination vs intracervical insemination | OR 2.55 [0.72, 8.96] | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision |
Multiple pregnancy rate Intrauterine insemination vs intracervical insemination | OR 2.77 [1, 7.69] | 2 studies · 131 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate Intrauterine insemination vs intracervical insemination | OR 2.83 [1.38, 5.78] | 2 studies · 131 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage rate Intrauterine insemination vs intracervical insemination | OR 1.97 [0.43, 9.04] | 2 studies · 131 participants | Very low Downgraded: risk of bias, imprecision |
Cancellation rate Intrauterine insemination vs intracervical insemination | no estimate extracted | NR | No studies |
Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day versus LH + 2 days
Population: women starting donor sperm treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day vs LH + 2 days | no estimate extracted | NR | No studies |
Multiple pregnancy rate Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day vs LH + 2 days | no estimate extracted | NR | No studies |
Clinical pregnancy rate Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day vs LH + 2 days | OR 2 [1.14, 3.53] | 1 study · 351 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage rate Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day vs LH + 2 days | no estimate extracted | NR | No studies |
Cancellation rate Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day vs LH + 2 days | no estimate extracted | NR | No studies |
Timing of intrauterine insemination with donor sperm: urinary luteinising hormone test versus temperature curve and cervical mucus score
Population: women starting donor sperm treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Timing of intrauterine insemination with donor sperm: urinary luteinising hormone test vs temperature curve and cervical mucus score | no estimate extracted | NR | No studies |
Multiple pregnancy rate Timing of intrauterine insemination with donor sperm: urinary luteinising hormone test vs temperature curve and cervical mucus score | no estimate extracted | NR | No studies |
Clinical pregnancy rate Timing of intrauterine insemination with donor sperm: urinary luteinising hormone test vs temperature curve and cervical mucus score | OR 1.31 [0.42, 4.11] | 1 study · 56 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Miscarriage rate Timing of intrauterine insemination with donor sperm: urinary luteinising hormone test vs temperature curve and cervical mucus score | no estimate extracted | NR | No studies |
Cancellation rate Timing of intrauterine insemination with donor sperm: urinary luteinising hormone test vs temperature curve and cervical mucus score | no estimate extracted | NR | No studies |