Cochrane · systematic review · CD013240
Long‐term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis
Georgiou, EX, Melo, P, Baker, PE, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Long‐term GnRH agonist therapy compared to no additional therapy in patients with endometriosis prior to standard in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI)
Population: patients with endometriosis prior to standard IVF/ICSI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate Long‐term GnRH agonist therapy vs no additional therapy | RR 0.48 [0.26, 0.87] | 1 study · 147 participants | Very low |
Complication rate Long‐term GnRH agonist therapy vs no additional therapy | Peto OR 1.23 [0.37, 4.14] | 3 studies · 318 participants | Very low Downgraded: imprecision, inconsistency |
Clinical pregnancy rate Long‐term GnRH agonist therapy vs no additional therapy | RR 1.13 [0.91, 1.41] | 6 studies · 552 participants | Very low Downgraded: imprecision, inconsistency |
Multiple pregnancy rate Long‐term GnRH agonist therapy vs no additional therapy | Peto OR 0.14 [0.04, 0.56] | 2 studies · 208 participants | Very low Downgraded: imprecision, inconsistency |
Miscarriage rate Long‐term GnRH agonist therapy vs no additional therapy | Peto OR 0.45 [0.1, 2] | 2 studies · 208 participants | Very low Downgraded: imprecision, inconsistency |
Mean number of oocytes Long‐term GnRH agonist therapy vs no additional therapy | no estimate extracted | 4 studies · 385 participants | Very low Downgraded: imprecision, inconsistency |
Mean number of embryos Long‐term GnRH agonist therapy vs no additional therapy | no estimate extracted | 2 studies · 267 participants | Very low Downgraded: imprecision, inconsistency |