Cochrane · systematic review · CD013226
Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction
Kamath, MS, Kirubakaran, R, Sunkara, SK · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 1 · 12.5%Very low 3 · 37.5%Low 3 · 37.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
G‐CSF compared to no treatment or placebo in subfertile women undergoing assisted reproduction
Population: subfertile women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Ongoing pregnancy rate per woman randomised G‐CSF vs no treatment or placebo | RR 1.62 [0.86, 3.08] | 1 study · 150 participants | Very low Downgraded: imprecision, indirectness |
Miscarriage rate per woman randomised G‐CSF vs no treatment or placebo | Peto OR 0.4 [0.09, 1.77] | 2 studies · 291 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Clinical pregnancy rate per woman randomised G‐CSF vs no treatment or placebo | RR 1.65 [1.32, 2.06] | 12 studies · 1050 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Clinical pregnancy rate ‐ unselected or unstated IVF number G‐CSF vs no treatment or placebo | RR 1.12 [0.75, 1.68] | 2 studies · 291 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate ‐ 2 or more IVF failures G‐CSF vs no treatment or placebo | RR 2.1 [1.53, 2.89] | 6 studies · 553 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate ‐ women with thin endometrium G‐CSF vs no treatment or placebo | RR 1.58 [0.95, 2.63] | 4 studies · 206 participants | Low Downgraded: risk of bias, imprecision |
Multiple pregnancy rate G‐CSF vs no treatment or placebo | no estimate extracted | NR | No studies |
Adverse events per woman randomised G‐CSF vs no treatment or placebo | no estimate extracted | 4 studies · 410 participants | Ungraded |