Cochrane · systematic review · CD009749
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction
Nagels, HE, Rishworth, JR, Siristatidis, CS, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 57.1%Low 1 · 7.1%Moderate 5 · 35.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
DHEA or testosterone versus placebo/no treatment for women undergoing assisted reproduction
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth/ongoing pregnancy rate ‐ DHEA DHEA or testosterone vs placebo/no treatment | OR 1.81 [1.25, 2.62] | 8 studies · 878 participants | Moderate Downgraded: imprecision |
Live birth/ongoing pregnancy rate ‐ Testosterone DHEA or testosterone vs placebo/no treatment | OR 2.6 [1.3, 5.2] | 4 studies · 345 participants | Moderate Downgraded: imprecision |
Miscarriage rate ‐ DHEA DHEA or testosterone vs placebo/no treatment | OR 0.58 [0.29, 1.17] | 8 studies · 950 participants | Moderate Downgraded: imprecision |
Miscarriage rate ‐ Testosterone DHEA or testosterone vs placebo/no treatment | OR 2.04 [0.58, 7.13] | 4 studies · 345 participants | Low Downgraded: imprecision |
Clinical pregnancy rate ‐ DHEA DHEA or testosterone vs placebo/no treatment | OR 1.34 [1.01, 1.76] | 12 studies · 1246 participants | Moderate Downgraded: imprecision |
Clinical pregnancy rate ‐ Testosterone DHEA or testosterone vs placebo/no treatment | OR 2.52 [1.36, 4.68] | 4 studies · 345 participants | Moderate Downgraded: imprecision |
Multiple pregnancy ‐ DHEA DHEA or testosterone vs placebo/no treatment | OR 3.23 [0.13, 81.01] | 5 studies · 267 participants | Very low Downgraded: imprecision |
Multiple pregnancy ‐ Testosterone DHEA or testosterone vs placebo/no treatment | OR 3.09 [0.48, 19.98] | 3 studies · 292 participants | Very low Downgraded: imprecision |
Testosterone compared to other active interventions for women undergoing assisted reproduction
Population: Women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth ‐ Testosterone vs estradiol Testosterone vs other active interventions | OR 2.06 [0.43, 9.87] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Live birth ‐ Testosterone vs estradiol + OCP Testosterone vs other active interventions | OR 1.67 [0.34, 8.1] | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage ‐ Testosterone vs estradiol Testosterone vs other active interventions | OR 0.7 [0.11, 4.64] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage ‐ Testosterone vs estradiol + OCP Testosterone vs other active interventions | OR 1.9 [0.16, 22.72] | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate ‐ Testosterone vs estradiol Testosterone vs other active interventions | OR 1.4 [0.39, 5.07] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate ‐ Testosterone vs estradiol + OCP Testosterone vs other active interventions | OR 1.87 [0.45, 7.69] | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision |