Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

34 questions · 35 findings · 19 reviews · Headline outcomes only

No studies found 6 · 17.1%GRADE not reported 2 · 5.7%Very low 6 · 17.1%Low 12 · 34.3%Moderate 8 · 22.9%High 1 · 2.9%

Summary of Findings Table ‐ Electrocoagulation alone vs control (vehicle solution of allopurinol by mouth)

All‐cause mortality at last · people with liver metastases

It is very uncertain whether summary of Findings Table ‐ Electrocoagulation alone changes all‐cause mortality at last compared with control (vehicle solution of allopurinol by mouth) (very low certainty).

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

All‐cause mortality within 3 months · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in all‐cause mortality within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Overall mortality ‐ only total mesorectal excision ( · People with localised rectal carcinoma

Preoperative radiotherapy showed no clear difference in overall mortality ‐ only total mesorectal excision ( compared with surgery alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

All‐cause mortality · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with mechanical bowel preparation alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs oral antibiotics

All‐cause mortality · Patients undergoing elective colorectal surgery

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with oral antibiotics alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Treatment of clinical and electrographic seizures vs treatment of clinical seizures alone

Mortality before hospital discharge · neonates

Summary of findings table ‐ Treatment of clinical and electrographic… showed no clear difference in mortality before hospital discharge compared with treatment of clinical seizures alone (low certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with fast breathing alone

Comparison 2: 7 days oral amoxicillin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review