Cochrane · systematic review · CD012464
Risk‐reducing bilateral salpingo‐oophorectomy in women with BRCA1 or BRCA2 mutations
Eleje, GU, Eke, AC, Ezebialu, IU, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
32
current version
GRADE rated
18
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 14 · 43.8%Very low 18 · 56.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Risk‐reducing salpingo‐oophorectomy (RRSO) versus no RRSO in BRCA1 or BRCA2 mutation carriers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival: BRCA1 or BRCA2 Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 0.32 [0.19, 0.54] | 3 studies · 2548 participants | Very low Downgraded: risk of bias |
HGSC mortality: BRCA1 or BRCA2 Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 0.06 [0.02, 0.17] | 3 studies · 2534 participants | Very low Downgraded: risk of bias |
Breast cancer mortality: BRCA1 or BRCA Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 0.58 [0.39, 0.88] | 7 studies · 7198 participants | Very low Downgraded: risk of bias |
Bone fracture incidence Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life (ovarian cancer risk perception): BRCA1 or BRCA2 Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 1 study · 200 participants | Very low Downgraded: risk of bias |
Quality of life (breast cancer risk perception): BRCA1 or BRCA2 Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 1 study · 200 participants | Very low Downgraded: risk of bias |
Severe adverse events Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Risk‐reducing salpingo‐oophorectomy (RRSO) versus no RRSO according to BRCA mutation status
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival: BRCA1 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | HR 0.3 [0.17, 0.52] | 3 studies · 2548 participants | Very low Downgraded: risk of bias |
Overall survival: BRCA2 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | HR 0.44 [0.23, 0.85] | 2 studies · 2122 participants | Very low Downgraded: risk of bias |
HGSC mortality: BRCA1 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | HR 0.1 [0.02, 0.41] | 2 studies · 1983 participants | Very low Downgraded: risk of bias |
HGSC mortality: BRCA2 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | no estimate extracted | 2 studies · 1983 participants | Very low Downgraded: risk of bias |
Breast cancer mortality: BRCA1 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | HR 0.45 [0.3, 0.67] | 4 studies · 2203 participants | Very low Downgraded: risk of bias |
Breast cancer mortality: BRCA2 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | HR 0.88 [0.42, 1.87] | 3 studies · 5882 participants | Very low Downgraded: risk of bias |
Quality of life (ovarian cancer risk perception): BRCA1 only Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status | no estimate extracted | 1 study · 98 participants | Very low Downgraded: risk of bias |
Risk‐reducing salpingo‐oophorectomy (RRSO) versus no RRSO in BRCA1 or BRCA2 mutation carriers according to type of risk‐reducing surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival: RRSO alone vs RRSO and RRM Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Overall survival: RRSO and RRM vs no RRSO Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 0.14 [0.02, 0.98] | 1 study · 261 participants | Very low Downgraded: risk of bias |
Breast cancer mortality: RRSO alone vs RRSO and RRM Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Breast cancer mortality: RRSO and RRM vs no RRSO Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 1 study · 722 participants | Very low Downgraded: risk of bias |
Bone fracture incidence Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Severe adverse events Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Risk‐reducing salpingo‐oophorectomy (RRSO) versus no RRSO in BRCA1 mutation carriers according to age at RRSO
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
HGSC mortality Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Breast cancer mortality: ≤ 50 years Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 0.78 [0.55, 1.09] | 3 studies · 4566 participants | Very low Downgraded: risk of bias |
Breast cancer mortality: > 50 years Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 1.27 [0.67, 2.38] | 3 studies · 4566 participants | Very low Downgraded: risk of bias |
Bone fracture incidence Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Severe adverse events Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Risk‐reducing salpingo‐oophorectomy (RRSO) versus no RRSO in BRCA2 mutation carriers according to age at RRSO
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
HGSC mortality Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Breast cancer mortality: ≤ 50 years Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 0.49 [0.08, 2.9] | 2 studies · 444 participants | Very low Downgraded: risk of bias |
Breast cancer mortality: > 50 years Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | HR 1.36 [0.68, 2.75] | 2 studies · 444 participants | Very low Downgraded: risk of bias |
Bone fracture incidence Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |
Severe adverse events Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO | no estimate extracted | 0 studies · 0 participants | Ungraded |