Cochrane · systematic review · CD003039
Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia
Mhaskar, R, Clark, OAugusto Camara, Lyman, G, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Benefits and harms of CSF plus antibiotics versus antibiotics alone
Population: people with chemotherapy‐induced febrile neutropenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality Benefits and harms of CSF plus antibiotics vs antibiotics alone | HR 0.74 [0.47, 1.16] | 13 studies · 1335 participants | Low Downgraded: risk of bias, imprecision |
Infection‐related mortality Benefits and harms of CSF plus antibiotics vs antibiotics alone | RR 0.75 [0.47, 1.2] | 10 studies · 897 participants | Low Downgraded: risk of bias, imprecision |
People hospitalized for > 10 days Benefits and harms of CSF plus antibiotics vs antibiotics alone | RR 0.65 [0.44, 0.95] | 7 studies · 1087 participants | Low Downgraded: imprecision |
Duration of grade IV neutropenia (lower values signify better outcomes) Benefits and harms of CSF plus antibiotics vs antibiotics alone | no estimate extracted | 9 studies · 1135 participants | Low Downgraded: imprecision |
Time to recovery from fever (lower values signify better outcomes) Benefits and harms of CSF plus antibiotics vs antibiotics alone | no estimate extracted | 9 studies · 966 participants | Low Downgraded: imprecision |
Time to withdrawal from ATB (lower values signify better outcomes) Benefits and harms of CSF plus antibiotics vs antibiotics alone | no estimate extracted | 3 studies · 457 participants | Low Downgraded: imprecision |
Deep vein thrombosis Benefits and harms of CSF plus antibiotics vs antibiotics alone | RR 1.68 [0.72, 3.93] | 4 studies · 389 participants | Low Downgraded: risk of bias, imprecision |