Cochrane · systematic review · CD009826
Treatment of Kaposi sarcoma in children with HIV‐1 infection
Anglemyer, A, Agrawal, AK, Rutherford, GW · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 16 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combination Chemotherapy + ART compared to Single Agent Chemotherapy + ART for Kaposi sarcoma in children with HIV‐1 infection
Population: Kaposi sarcoma in children with HIV‐1 infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Combination Chemotherapy + ART vs Single Agent Chemotherapy + ART | RR 0.38 [0.24, 0.58] | 50 participants | Very low |
Vincristine + ART compared to Bleomycin + vincristine + ART for Kaposi sarcoma in children with HIV‐1 infection
Population: Kaposi sarcoma in children with HIV‐1 infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete: Vincristine+ART vs Bleomycin+vincristine+ART Vincristine + ART vs Bleomycin + vincristine + ART | RR 0.69 [0.33, 1.47] | 26 participants | Very low |
Complete/Partial: Vincristine+ART vs Bleomycin+vincristine+ART Vincristine + ART vs Bleomycin + vincristine + ART | RR 0.79 [0.52, 1.2] | 26 participants | Very low |
ART alone compared to Vincristine or Bleomycin for Kaposi sarcoma in children with HIV‐1 infection
Population: Kaposi sarcoma in children with HIV‐1 infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete Response ART alone vs Vincristine or Bleomycin | RR 1.2 [0.13, 11.43] | 24 participants | Very low |
Complete or Partial Response ART alone vs Vincristine or Bleomycin | RR 0.2 [0.05, 0.79] | 24 participants | Very low |
Chemotherapy + ART compared to ART for Kaposi sarcoma in children with HIV‐1 infection
Population: Kaposi sarcoma in children with HIV‐1 infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete Response to Tx Chemotherapy + ART vs ART | RR 1.57 [0.22, 11.34] | 89 participants | Very low |
Complete/Partial Response to Tx Chemotherapy + ART vs ART | RR 5.75 [1.59, 20.73] | 39 participants | Very low |
Complete Among Known Outcome Chemotherapy + ART vs ART | RR 0.84 [0.48, 1.48] | 26 participants | Very low |
Complete/Partial Among Known Outcome Chemotherapy + ART vs ART | RR 1.13 [0.67, 1.89] | 26 participants | Very low |
Mean CD4% Increase During Chemo Chemotherapy + ART vs ART | no estimate extracted | 48 participants | Very low |
Mortality Chemotherapy + ART vs ART | RR 0.72 [0.37, 1.43] | 50 participants | Very low |
Chemotherapy + ART compared to Chemotherapy Alone for Kaposi sarcoma in children with HIV‐1 infection
Population: Kaposi sarcoma in children with HIV‐1 infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete Response to Tx Chemotherapy + ART vs Chemotherapy Alone | RR 6.54 [1, 42.86] | 36 participants | Very low Downgraded: imprecision |
Complete/Partial Response to Tx Chemotherapy + ART vs Chemotherapy Alone | RR 1.47 [0.87, 2.49] | 36 participants | Very low Downgraded: imprecision |
Complete Among Known Outcome Chemotherapy + ART vs Chemotherapy Alone | RR 4.25 [0.7, 25.91] | 30 participants | Very low Downgraded: imprecision |
Complete/Partial Among Known Outcome Chemotherapy + ART vs Chemotherapy Alone | RR 1.01 [0.81, 1.27] | 30 participants | Very low Downgraded: imprecision |
Mortality Chemotherapy + ART vs Chemotherapy Alone | RR 0.46 [0.29, 0.73] | 98 participants | Very low Downgraded: imprecision |