Cochrane · systematic review · CD002102
Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma
Abraha, I, Aristei, C, Palumbo, I, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
ColorectalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 77.8%Moderate 2 · 22.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Preoperative radiotherapy compared to surgery alone for the management of localised rectal carcinoma
Population: People with localised rectal carcinoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality ( Preoperative radiotherapy vs surgery alone | Peto OR 0.9 [0.83, 0.98] | 4 studies · 4663 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Overall mortality ‐ only total mesorectal excision ( Preoperative radiotherapy vs surgery alone | Peto OR 0.97 [0.87, 1.08] | 2 studies · 3211 participants | Low Downgraded: imprecision, indirectness |
Cause‐specific mortality ( Preoperative radiotherapy vs surgery alone | Peto OR 0.89 [0.77, 1.03] | 2 studies · 2145 participants | Low Downgraded: imprecision, indirectness |
Local recurrence ( Preoperative radiotherapy vs surgery alone | Peto OR 0.48 [0.4, 0.57] | 4 studies · 4663 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Curative resection ( Preoperative radiotherapy vs surgery alone | RR 1 [0.97, 1.02] | 4 studies · 4673 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Sphincter preservation ( Preoperative radiotherapy vs surgery alone | RR 0.99 [0.94, 1.04] | 3 studies · 4379 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Postoperative morbidity ‐ sepsis (within 30 days after surgery) Preoperative radiotherapy vs surgery alone | RR 1.25 [1.04, 1.52] | 2 studies · 2698 participants | Low Downgraded: risk of bias, indirectness |
Postoperative morbidity ‐ surgical complications (within 30 days after surgery) Preoperative radiotherapy vs surgery alone | RR 1.2 [1.01, 1.42] | 2 studies · 2698 participants | Low Downgraded: risk of bias, indirectness |
Quality of life ( Preoperative radiotherapy vs surgery alone | no estimate extracted | 2 studies · 3211 participants | Low Downgraded: risk of bias, indirectness |