Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

232 questions · 237 findings · 121 reviews

No studies found 34 · 14.3%GRADE not reported 13 · 5.5%Very low 82 · 34.6%Low 66 · 27.8%Moderate 30 · 12.7%High 12 · 5.1%

Ultra‐radical (extensive) surgery vs surgery

Perioperative mortality · women with stage IIIc or IV ovarian cancer

It is very uncertain whether ultra‐radical (extensive) surgery changes adverse event: perioperative mortality compared with standard surgery (very low certainty).

1 finding from 1 review

Pre-operative radiotherapy (plus surgery) vs surgery

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

All‐cause mortality up to 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Mortality (within 30 days after surgery) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in mortality (within 30 days after surgery) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

Beta‐blockers vs control—cardiac surgery

All‐cause mortality (30 days)—cardiac surgery · patients with coronary heart disease and/or valvular heart disease

Beta‐blocker showed no clear difference in all‐cause mortality (30 days)—cardiac surgery compared with control—cardiac surgery (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

All‐cause mortality (within 30‐days after surgery: any reported death) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in all‐cause mortality (within 30‐days after surgery: any reported death) compared with control (moderate certainty).

1 finding from 1 review

Remote ischaemic preconditioning (RIPC) vs no RIPC

Composite endpoint (including all‐cause mortality, non‐fatal myocardial infarction and/or any new stroke assessed at 30 days after surgery) · people undergoing CABG (with or without valve surgery)

RIPC showed no clear difference in composite endpoint (including all‐cause mortality, non‐fatal… compared with no RIPC (moderate certainty).

1 finding from 1 review