Cochrane · systematic review · CD004561
Axillary treatment for operable primary breast cancer
Bromham, N, Schmidt‐Hansen, M, Astin, M, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 14.3%Low 6 · 42.9%Moderate 4 · 28.6%High 2 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
No axillary surgery compared with full axillary surgery for operable primary breast cancer
Population: women with operable primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality No axillary surgery vs full axillary surgery | HR 1.06 [0.96, 1.17] | 10 studies · 3849 participants | Moderate |
Locoregional recurrence No axillary surgery vs full axillary surgery | HR 2.35 [1.91, 2.89] | 5 studies · 20863 participants | Moderate Downgraded: inconsistency |
Lymphoedema Increase in arm circumference No axillary surgery vs full axillary surgery | OR 0.31 [0.23, 0.43] | 4 studies · 1714 participants | Low Downgraded: risk of bias, inconsistency |
Arm or shoulder movement impairment No axillary surgery vs full axillary surgery | OR 0.72 [0.49, 1.05] | 5 studies · 1495 participants | Very low Downgraded: risk of bias, inconsistency |
Axillary sampling compared with full axillary surgery for operable primary breast cancer
Population: women with operable primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Axillary sampling vs full axillary surgery | HR 0.94 [0.73, 1.21] | 3 studies · 967 participants | Low Downgraded: inconsistency |
Local recurrence Axillary sampling vs full axillary surgery | HR 1.41 [0.94, 2.12] | 3 studies · 1404 participants | Low Downgraded: risk of bias |
Sentinel node biopsy compared with full axillary surgery for operable primary breast cancer
Population: women with operable primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Sentinel node biopsy vs full axillary surgery | HR 1.05 [0.89, 1.25] | 3 studies · 6352 participants | Moderate |
Lymphoedema Patient‐reported lymphoedema of any severity Sentinel node biopsy vs full axillary surgery | OR 0.33 [0.15, 0.86] | 3 studies · 815 participants | Low |
Subjective arm movement impairment Sentinel node biopsy vs full axillary surgery | OR 0.38 [0.22, 0.67] | 2 studies · 877 participants | Very low Downgraded: risk of bias, inconsistency |
Paraesthesia Sentinel node biopsy vs full axillary surgery | OR 0.15 [0.09, 0.23] | 2 studies · 495 participants | Low Downgraded: risk of bias, inconsistency |
Pain Sentinel node biopsy vs full axillary surgery | OR 0.44 [0.3, 0.67] | 2 studies · 877 participants | Low Downgraded: risk of bias, inconsistency |
Numbness Sentinel node biopsy vs full axillary surgery | OR 0.43 [0.34, 0.54] | 3 studies · 1799 participants | Moderate |
Radiotherapy alone compared with full axillary surgery for operable primary breast cancer
Population: women with operable primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Radiotherapy alone vs full axillary surgery | HR 1.1 [1, 1.21] | 4 studies · 2469 participants | High |
Local recurrence Radiotherapy alone vs full axillary surgery | HR 0.8 [0.64, 0.99] | 4 studies · 22256 participants | High |