Cochrane · systematic review · CD007697
Ultra‐radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer
Hiu, S, Bryant, A, Gajjar, K, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
6
No studies
3
Included studies
NR
No studies 3 · 33.3%Ungraded 0 · 0%Very low 5 · 55.6%Low 0 · 0%Moderate 0 · 0%High 1 · 11.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ultra‐radical (extensive) surgery compared to standard surgery in women with stage IIIc or IV ovarian cancer
Population: women with stage IIIc or IV ovarian cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Survival (overall and disease‐ specific) Ultra‐radical (extensive) surgery vs standard surgery | HR 0.6 [0.43, 0.82] | 2 studies · 397 participants | Very low Downgraded: risk of bias, imprecision |
Progression‐free survival Ultra‐radical (extensive) surgery vs standard surgery | HR 0.62 [0.42, 0.92] | 1 study · 203 participants | Very low Downgraded: risk of bias, imprecision |
Disease‐free survival Ultra‐radical (extensive) surgery vs standard surgery | HR 1.6 [1.11, 2.31] | 1 study · 527 participants | Very low Downgraded: risk of bias, imprecision |
Rate of optimal cytoreduction Ultra‐radical (extensive) surgery vs standard surgery | no estimate extracted | NR | High |
Recurrence rate Ultra‐radical (extensive) surgery vs standard surgery | no estimate extracted | NR | No studies |
(Loco)regional control Ultra‐radical (extensive) surgery vs standard surgery | no estimate extracted | NR | No studies |
Adverse event: perioperative mortality Ultra‐radical (extensive) surgery vs standard surgery | no estimate extracted | 2 studies · 397 participants | Very low Downgraded: risk of bias, imprecision |
Adverse event: serious postoperative morbidity Ultra‐radical (extensive) surgery vs standard surgery | RR 3.24 [1.84, 5.68] | 1 study · 203 participants | Very low Downgraded: risk of bias, imprecision |
Quality of Life Ultra‐radical (extensive) surgery vs standard surgery | no estimate extracted | NR | No studies |