Benefits and harms of CSF plus antibiotics showed no clear difference in overall mortality compared with antibiotics alone (low certainty).
Benefits and harms of CSF plus antibiotics showed no clear difference in infection‐related mortality compared with antibiotics alone (low certainty).
The review found no eligible studies for this question.
It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality compared with placebo or no intervention (very low certainty).
Mortality with anti‐gram‐positive antibiotics showed no clear difference in overall mortality compared with placebo (moderate certainty).
It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics (very low certainty).
It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes all‐cause mortality during hospital stay compared with pentoxifylline with antibiotics and immunoglobulin M‐enriched… (very low certainty).
Summary of findings: antibiotics leads to lower all cause mortality compared with placebo or no intervention (high certainty).
Summary of findings table ‐ Antibiotics showed no clear difference in all‐cause mortality compared with placebo or no intervention (low certainty).
It is very uncertain whether comparison 1: referral or full course of antibiotics changes neonatal mortality ‐ full course compared with standard care (very low certainty).
Pentoxifylline with antibiotics (any dose or duration) may leads to lower all‐cause mortality during hospital stay compared with placebo or no intervention (low certainty).
Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).
Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).
Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).
Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with oral antibiotics alone (low certainty).