Cochrane · systematic review · CD004386
Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy
Gafter‐Gvili, A, Fraser, A, Paul, M, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 66.7%High 2 · 33.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: antibiotics versus placebo or no intervention
Population: patients with afebrile neutropenia induced by chemotherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All cause mortality Summary of findings: antibiotics vs placebo or no intervention | RR 0.66 | 46 studies · 5635 participants | High |
Febrile patients and episodes Summary of findings: antibiotics vs placebo or no intervention | RR 0.8 | 54 studies · 6658 participants | Moderate |
Bacteraemia Summary of findings: antibiotics vs placebo or no intervention | RR 0.5 | 53 studies · 6390 participants | High |
Summary of findings: quinolone prophylaxis compared with TMP‐SMZ prophylaxis
Population: cancer patients with afebrile neutropenia following chemotherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All cause‐mortality Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis | RR 1.07 | 10 studies · 917 participants | Moderate Downgraded: risk of bias |
Febrile patients and episodes Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis | RR 0.92 | 10 studies · 931 participants | Moderate Downgraded: risk of bias |
Bacteraemia Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis | RR 0.89 | 10 studies · 931 participants | Moderate Downgraded: risk of bias |