Cochrane · systematic review · CD003914
Empirical antibiotics targeting gram‐positive bacteria for the treatment of febrile neutropenic patients with cancer
Beyar‐Katz, O, Dickstein, Y, Borok, S, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 50%Low 1 · 25%Moderate 1 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mortality with anti‐gram‐positive antibiotics compared to placebo for the treatment of febrile neutropenic patients with cancer
Population: febrile neutropenic patients with cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall mortality Mortality with anti‐gram‐positive antibiotics vs placebo | RR 0.9 [0.64, 1.25] | 8 studies · 1242 participants | Moderate Downgraded: risk of bias |
Treatment failure with anti‐gram‐positive antibiotics compared to placebo for the treatment of febrile neutropenic patients with cancer
Population: febrile neutropenic patients with cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall failure (disregarding modifications) Treatment failure with anti‐gram‐positive antibiotics vs placebo | RR 1 [0.79, 1.27] | 7 studies · 943 participants | Low Downgraded: risk of bias |
Failure, modifications included Treatment failure with anti‐gram‐positive antibiotics vs placebo | RR 0.72 [0.65, 0.79] | 11 studies · 2169 participants | Very low Downgraded: risk of bias |
Adverse events with anti‐gram‐positive antibiotics compared to placebo for the treatment of febrile neutropenic patients with cancer
Population: febrile neutropenic patients with cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any adverse events Adverse events with anti‐gram‐positive antibiotics vs placebo | RR 1.74 [1.5, 2.01] | 9 studies · 1936 participants | Very low Downgraded: risk of bias |