What do systematic reviews say?

Morphine vs fentanyl

The review found no eligible studies for this question.

• Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioids vs placebo or no treatment

• Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1259 participants
  Moderate

Morphine vs diamorphine

The review found no eligible studies for this question.

• Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Fentanyl vs sufentanil

• Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Fentanyl vs remifentanil

The review found no eligible studies for this question.

• Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Opioids vs other analgesics and sedatives

• Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Very low

Intervention not reported

• Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 294 participants
  Moderate

Etomidate vs all other induction agents

• Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 621 participants
  Moderate

Probiotics vs control

• Probiotics for preventing ventilator‐associated pneumonia 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 203 participants
  Very low

Intervention not reported

• N‐acetylcysteine for sepsis and systemic inflammatory response in adults 2012 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 423 participants
  Moderate

Post‐pyloric tube feeding vs gastric tube feeding

• Post‐pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 549 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in total duration of mechanical ventilation (days) (low certainty).

• Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
  no estimate extracted
  37 participants
  Low

Intervention not reported

• Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants 2016 · Cochrane Headline outcomes only
  no estimate extracted
  21 participants
  Low

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

Daily sedation interruption showed no clear difference in total duration of mechanical ventilation (days) compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

• Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive… 2014 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 1282 participants
  Moderate

Statins vs control

• Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Low

Corticosteroids vs control

• Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 277 participants
  Very low

Surfactants vs control

• Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  Very low

Bispectral index vs treatment guided by clinical assessment alone?

BIS monitoring showed no clear difference in duration of mechanical ventilation (measured in days) compared with clinical assessment (low certainty).

• BIS monitoring versus clinical assessment for sedation in mechanically ventilated adults in the intensive care unit… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 155 participants
  Low

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

Early enteral nutrition vs delayed enteral nutrition

• Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 125 participants
  Very low