Cochrane · systematic review · CD010225
Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients
Bruder, EA, Ball, IM, Ridi, S, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 85.7%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Etomidate versus all other induction agents for endotracheal intubation in critically ill patients
Population: patients with endotracheal intubation in critically ill patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Etomidate vs all other induction agents | OR 1.17 [0.86, 1.6] | 6 studies · 772 participants | Moderate |
ACTH stimulation test ACTH stimulation test is considered positive if the change in serum cortisol level was less than 9 μg/dL (248 nmol/L) after the administration of 250 μg of cosyntropin Etomidate vs all other induction agents | OR 2.37 [1.61, 3.47] | 3 studies · 519 participants | Moderate |
Random serum cortisol levels (μg/dL) after receiving intervention Etomidate vs all other induction agents | no estimate extracted | 3 studies · 105 participants | Moderate |
Organ system dysfunction Sequential Organ Failure Assessment (SOFA) Score. Scale from: 1 to 24 Etomidate vs all other induction agents | no estimate extracted | 1 study · 469 participants | High |
ICU length of stay (days) Etomidate vs all other induction agents | no estimate extracted | 3 studies · 621 participants | Moderate |
Hospital length of stay (days) Etomidate vs all other induction agents | no estimate extracted | 2 studies · 152 participants | Moderate |
Duration of mechanical ventilation (days) Etomidate vs all other induction agents | no estimate extracted | 3 studies · 621 participants | Moderate |