Cochrane · systematic review · CD009066
Probiotics for preventing ventilator‐associated pneumonia
Bo, L, Li, J, Tao, T, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Per‐protocol analysis: probiotics versus control for preventing ventilator‐associated pneumonia
Population: patients receiving mechanical ventilation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of VAP Per‐protocol analysis: probiotics vs control | OR 0.7 [0.52, 0.95] | 8 studies · 1018 participants | Low Downgraded: risk of bias, indirectness |
ICU mortality Per‐protocol analysis: probiotics vs control | OR 0.84 [0.58, 1.22] | 5 studies · 703 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Hospital mortality Per‐protocol analysis: probiotics vs control | OR 0.78 [0.54, 1.14] | 4 studies · 524 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Diarrhoea Per‐protocol analysis: probiotics vs control | OR 0.72 [0.47, 1.09] | 4 studies · 618 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Length of ICU stay (days) Per‐protocol analysis: probiotics vs control | no estimate extracted | 4 studies · 396 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Duration of mechanical ventilation (days) Per‐protocol analysis: probiotics vs control | no estimate extracted | 2 studies · 203 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Antibiotic use Per‐protocol analysis: probiotics vs control | OR 1.23 [0.51, 2.96] | 1 study · 259 participants | Low Downgraded: risk of bias |