Cochrane · systematic review · CD009176
Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation
Burry, L, Rose, L, McCullagh, IJ, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Daily sedation interruption compared to usual care or protocolized sedation strategies that do not include daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation
Population: critically ill adult patients requiring invasive mechanical ventilation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total duration of mechanical ventilation (days) Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption | no estimate extracted | 9 studies · 1282 participants | Moderate |
ICU length of stay (days) Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption | no estimate extracted | 9 studies · 1282 participants | Moderate |
Hospital length of stay (days) Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption | no estimate extracted | 8 studies · 1232 participants | Moderate |
Tracheostomy Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption | RR 0.73 [0.57, 0.92] | 6 studies · 1061 participants | Moderate |
Accidental removal of ETT Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption | RR 1.07 [0.55, 2.12] | 6 studies · 1108 participants | Moderate |
ICU mortality Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption | RR 0.96 [0.77, 1.21] | 7 studies · 815 participants | Moderate |