Adverse events
It is very uncertain whether paracetamol changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
Any adverse events Up to 12 weeks' · Patients with acute low‐back pain
Paracetamol showed no clear difference in any adverse events Up to 12 weeks' compared with placebo (high certainty).
1 finding from 1 review
Serious adverse events Up to 12 weeks' · Patients with acute low‐back pain
Paracetamol showed no clear difference in serious adverse events Up to 12 weeks' compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).
1 finding from 1 review
Total adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in total adverse events: number experiencing 24 weeks compared with placebo (high certainty).
1 finding from 1 review
Serious adverse events: number experiencing 24 weeks · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in serious adverse events: number experiencing 24 weeks compared with placebo (moderate certainty).
1 finding from 1 review
Neonatal adverse events · women who have given birth vaginally, requiring analgesia for after‐birth pains.
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Neonatal adverse events · women who have given birth vaginally, requiring analgesia for after‐birth pains.
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse events · adults with episodic tension‐type headache
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Maternal adverse events · women who have given birth vaginally, requiring analgesia for after‐birth pains.
It is very uncertain whether paracetamol changes maternal adverse events (up to 4 hours and at 6 hours) compared with placebo (very low certainty).
1 finding from 1 review
Maternal adverse events · women who have given birth vaginally, requiring analgesia for after‐birth pains.
It is very uncertain whether paracetamol changes maternal adverse events (up to 4 hours and at 6 hours) compared with NSAID (very low certainty).
1 finding from 1 review
Serious adverse events · adults with episodic tension‐type headache
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Serious adverse events · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Adverse events
It is very uncertain whether NSAIDs changes adverse events compared with paracetamol (very low certainty).
1 finding from 1 review
Serious adverse events · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse events · children with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Non‐serious adverse events · children with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine showed no clear difference in non‐serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Non‐serious adverse events · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure
N‐acetylcysteine showed no clear difference in non‐serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Adverse events
It is very uncertain whether NSAIDs changes adverse events compared with placebo (very low certainty).
1 finding from 1 review
Intervention not reported
Adverse events · people with cancer pain
1 finding from 1 review