Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

173 questions · 180 findings · 91 reviews

No studies found 50 · 27.8%GRADE not reported 15 · 8.3%Very low 56 · 31.1%Low 42 · 23.3%Moderate 13 · 7.2%High 4 · 2.2%

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Adverse events · All patients with cancer who are receiving treatment
2 findings from 1 review

Four per cent chlorhexidine + hand hygiene promotion vs usual care

Authors reported adverse outcomes (events without hospitalisation) · Neonates and caregivers

It is very uncertain whether four per cent chlorhexidine + hand hygiene promotion changes authors reported adverse outcomes (events without hospitalisation) compared with usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review