Cochrane · systematic review · CD012393
Interventions for autumn exacerbations of asthma in children
Pike, KC, Akhbari, M, Kneale, D, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
9
No studies
3
Included studies
NR
No studies 3 · 25%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 8.3%Moderate 7 · 58.3%High 1 · 8.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Omalizumab compared to usual care for autumn asthma exacerbations in children
Population: autumn asthma exacerbations in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations Omalizumab vs usual care | OR 0.48 [0.25, 0.92] | 1 study · 348 participants | Moderate Downgraded: imprecision |
Exacerbations Omalizumab vs usual care | OR 0.37 [0.17, 0.81] | 1 study · 184 participants | Moderate Downgraded: imprecision |
Exacerbations Omalizumab vs usual care | OR 0.63 [0.22, 1.79] | 1 study · 164 participants | Moderate Downgraded: imprecision |
Adverse events Omalizumab vs usual care | OR 0.99 [0.61, 1.58] | 1 study · 361 participants | Moderate Downgraded: imprecision |
A boost of inhaled corticosteroids compared to usual care for autumn asthma exacerbations in children
Population: autumn asthma exacerbations in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations A boost of inhaled corticosteroids vs usual care | OR 0.86 [0.32, 2.3] | 1 study · 173 participants | Moderate Downgraded: imprecision |
Adverse events A boost of inhaled corticosteroids vs usual care | OR 0.67 [0.34, 1.33] | 1 study · 176 participants | Moderate Downgraded: imprecision |
Leukotriene receptor antagonist compared to usual care for autumn asthma exacerbations in children
Population: autumn asthma exacerbations in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations Leukotriene receptor antagonist vs usual care | no estimate extracted | NR | No studies |
Exacerbations Leukotriene receptor antagonist vs usual care | OR 0.5 [0.17, 1.46] | 2 studies · 1326 participants | Low Downgraded: inconsistency, indirectness |
Adverse events Leukotriene receptor antagonist vs usual care | OR 0.91 [0.63, 1.32] | 2 studies · 1326 participants | High |
Behavioural intervention compared to usual care for autumn asthma exacerbations in children
Population: autumn asthma exacerbations in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exacerbations Behavioural intervention vs usual care | no estimate extracted | NR | No studies |
Exacerbations Behavioural intervention vs usual care | OR 1.13 [0.95, 1.33] | 1 study · 10481 participants | Moderate Downgraded: indirectness |
Adverse events Behavioural intervention vs usual care | no estimate extracted | NR | No studies |