Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,514 questions · 1,543 findings · 649 reviews

No studies found 224 · 14.5%GRADE not reported 105 · 6.8%Very low 383 · 24.8%Low 447 · 29%Moderate 293 · 19%High 91 · 5.9%

Probiotics vs placebo

Withdrawals due to adverse events · children with chronic constipation without a physical explanation

Probiotic showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Belimumab 10 mg/kg vs placebo

Withdrawals due to adverse events · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

All doses of cerivastatin vs placebo

Withdrawals due to adverse events · participants with normal or abnormal lipid profiles

It is very uncertain whether all doses of cerivastatin changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Adalimumab vs placebo

Withdrawals due to adverse events · Participants with Crohn's disease in remission

Adalimumab probably leads to lower withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Valproate vs placebo

Serious adverse events by 6 weeks · people with agitation in dementia

It is very uncertain whether valproate preparations changes serious adverse events by 6 weeks compared with placebo (very low certainty).

1 finding from 1 review