evidence/gaps
Cochrane · systematic review · CD003945

Valproate preparations for agitation in dementia

Baillon, SF, Narayana, U, Luxenberg, JS, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library

Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 1 · 14.3%Moderate 3 · 42.9%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Valproate preparations compared to placebo for agitation in dementia

Population: people with agitation in dementia
7 questions
OutcomeEffectEvidenceStatus / GRADE
Agitation and aggression
Valproate preparations vs placebo
no estimate extracted2 studies · 202 participantsModerate
Downgraded: imprecision
Agitation and aggression
Valproate preparations vs placebo
no estimate extracted2 studies · 202 participantsModerate
Downgraded: imprecision
Agitation and aggression
Valproate preparations vs placebo
no estimate extracted3 studies · 217 participantsVery low
Downgraded: imprecision
Cognition
Valproate preparations vs placebo
no estimate extracted3 studies · 217 participantsVery low
Downgraded: imprecision
Functional performance
Valproate preparations vs placebo
no estimate extracted2 studies · 203 participantsModerate
Downgraded: imprecision
Any adverse event by 6 weeks
Valproate preparations vs placebo
OR 2.02 [1.3, 3.14]3 studies · 381 participantsLow
Downgraded: risk of bias, imprecision, inconsistency
Serious adverse events by 6 weeks
Valproate preparations vs placebo
OR 4.77 [1, 22.74]2 studies · 228 participantsVery low
Downgraded: imprecision