Cochrane · systematic review · CD013743
Antibiotics for the induction and maintenance of remission in ulcerative colitis
Gordon, M, Sinopoulou, V, Grafton-Clarke, C, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
11
No studies
5
Included studies
NR
No studies 5 · 20.8%Ungraded 8 · 33.3%Very low 7 · 29.2%Low 3 · 12.5%Moderate 0 · 0%High 1 · 4.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics compared to placebo for the induction of remission in ulcerative colitis
Population: people with active UC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to induce clinical remission at end of study Antibiotics vs placebo | RR 0.88 [0.74, 1.06] | 7 studies · 608 participants | High |
Failure to induce clinical response at end of study Antibiotics vs placebo | RR 0.75 [0.47, 1.22] | 3 studies · 343 participants | Low Downgraded: imprecision, inconsistency |
Serious adverse events Antibiotics vs placebo | RR 1.19 [0.38, 3.71] | 8 studies · 691 participants | Low Downgraded: imprecision |
Withdrawals due to adverse events Antibiotics vs placebo | RR 2.06 [0.27, 15.72] | 8 studies · 691 participants | Low Downgraded: imprecision |
Antibiotics plus probiotics compared to placebo or no intervention for the induction of remission in ulcerative colitis
Population: people with active UC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to induce clinical remission at end of study Antibiotics plus probiotics vs placebo or no intervention | RR 0.68 [0.39, 1.19] | 2 studies · 98 participants | Very low Downgraded: risk of bias, imprecision |
Failure to induce clinical response at end of study Antibiotics plus probiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Serious adverse events Antibiotics plus probiotics vs placebo or no intervention | RR 1 [0.07, 15.08] | 2 studies · 98 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawals due to adverse events Antibiotics plus probiotics vs placebo or no intervention | RR 1 [0.07, 15.08] | 2 studies · 98 participants | Very low Downgraded: risk of bias, imprecision |
Antibiotics compared to 5‐ASA for the induction of remission in ulcerative colitis
Population: people with active UC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to induce clinical remission at end of study Antibiotics vs 5‐ASA | no estimate extracted | NR | No studies |
Failure to induce clinical response at end of study Antibiotics vs 5‐ASA | RR 2.2 [1.17, 4.14] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Antibiotics vs 5‐ASA | no estimate extracted | 1 study · 46 participants | Ungraded |
Withdrawals due to adverse events Antibiotics vs 5‐ASA | no estimate extracted | 1 study · 46 participants | Ungraded |
Antibiotics compared to probiotics for the induction of remission in ulcerative colitis
Population: people with active UC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to induce clinical remission at end of study Antibiotics vs probiotics | RR 0.47 [0.23, 0.94] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |
Failure to induce clinical response at end of study Antibiotics vs probiotics | no estimate extracted | NR | No studies |
Serious adverse events Antibiotics vs probiotics | no estimate extracted | 1 study · 50 participants | Ungraded |
Withdrawals due to adverse events Antibiotics vs probiotics | no estimate extracted | 1 study · 50 participants | Ungraded |
Antibiotics compared to 5‐ASA for the maintenance of remission in ulcerative colitis
Population: people with UC in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to maintain clinical remission at end of study Antibiotics vs 5‐ASA | RR 0.71 [0.47, 1.06] | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision |
Failure to maintain clinical response at end of study Antibiotics vs 5‐ASA | no estimate extracted | NR | No studies |
Serious adverse events Antibiotics vs 5‐ASA | no estimate extracted | 1 study · 40 participants | Ungraded |
Withdrawals due to adverse events Antibiotics vs 5‐ASA | no estimate extracted | 1 study · 40 participants | Ungraded |
Antibiotics compared to no treatment for a mixed population of active and inactive people with ulcerative colitis
Population: of active and inactive people with ulcerative colitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure to induce clinical remission at end of study Antibiotics vs no treatment | RR 0.56 [0.29, 1.07] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Failure to induce clinical response at end of study Antibiotics vs no treatment | no estimate extracted | NR | No studies |
Serious adverse events Antibiotics vs no treatment | no estimate extracted | 1 study · 20 participants | Ungraded |
Withdrawals due to adverse events Antibiotics vs no treatment | no estimate extracted | 1 study · 20 participants | Ungraded |