Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

137 questions · 138 findings · 58 reviews

No studies found 23 · 16.7%GRADE not reported 4 · 2.9%Very low 35 · 25.4%Low 31 · 22.5%Moderate 34 · 24.6%High 11 · 8%

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to the patient or HCW before and/or after an AGP vs No treatment or saline or water

Other adverse events (allergy, irritation/burning of nasal, oral or oropharyngeal mucosa, long-term staining of mucous membranes or teeth, accidental ingestion) · Patients without suspected or confirmed COVID-19 infection undergoing aerosol-generating procedures (AGPs), and the healthcare workers…

The review found no eligible studies for this question.

1 finding from 1 review

Any antimicrobial mouthwash and/or nasal spray (alone or in combination), at any concentration, delivered to healthcare workers, with or without the same intervention given to the patients with COVID-19 vs No treatment or saline or water

Other adverse events (allergy, irritation/burning of nasal, oral or oropharyngeal mucosa, long-term staining of mucous membranes or teeth, accidental ingestion) · Healthcare workers (HCWs) treating patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Adverse events during treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes neurological adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention may leads to higher incidence of adverse events compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of adverse events compared with hospital intervention (low certainty).

1 finding from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes gastrointestinal adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review