Cochrane · systematic review · CD009568
Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children
Bélard, S, Ramharter, M, Kurth, F · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 16.7%Very low 0 · 0%Low 4 · 66.7%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table 1
Population: children aged 14 years or younger with uncomplicated P falciparum malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure day‐28 PCR‐adjusted(PP population) | RR 1.35 [0.49, 3.72] | 2 studies · 1061 participants | Low Downgraded: imprecision |
Treatment failureday‐28 PCR‐adjusted(ITT population) | RR 1.05 [0.68, 1.62] | 2 studies · 1139 participants | Low Downgraded: imprecision |
Serious adverse events | RR 1.05 [0.38, 2.88] | 2 studies · 1197 participants | Low Downgraded: imprecision |
Drug‐related adverse events | RR 0.78 [0.62, 0.99] | 2 studies · 1197 participants | Moderate Downgraded: imprecision |
Drug‐related vomiting | RR 0.75 [0.56, 1.01] | 2 studies · 1197 participants | Low Downgraded: imprecision |
Acceptability | no estimate extracted | 0 studies · 0 participants | Ungraded |